Analyzing the relationship between decorrelation time and tissue thickness in acute rat brain slices using multispeckle diffusing wave spectroscopy

Brake, Joshua and Jang, Mooseok and Yang, Changhuei (2016) Analyzing the relationship between decorrelation time and tissue thickness in acute rat brain slices using multispeckle diffusing wave spectroscopy. Journal of the Optical Society of America A, 33 (2). pp. 270-275. ISSN 1084-7529. PMCID PMC4783160. https://resolver.caltech.edu/CaltechAUTHORS:20160218-123702274

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Abstract

Novel techniques in the field of wavefront shaping have enabled light to be focused deep inside or through scattering media such as biological tissue. However, most of these demonstrations have been limited to thin, static samples since these techniques are very sensitive to changes in the arrangement of the scatterers within. As the samples of interest get thicker, the influence of the dynamic nature of the sample becomes even more pronounced and the window of time in which the wavefront solutions remain valid shrinks further. In this paper, we examine the time scales upon which this decorrelation happens in acute rat brain slices via multispeckle diffusing wave spectroscopy and investigate the relationship between this decorrelation time and the thickness of the sample using diffusing wave spectroscopy theory and Monte Carlo photon transport simulation.

Item Type:

Article

Related URLs:

URL	URL Type	Description
http://dx.doi.org/10.1364/JOSAA.33.000270	DOI	Article
https://www.osapublishing.org/josaa/abstract.cfm?uri=josaa-33-2-270	Publisher	Article
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783160/	PubMed Central	Article

ORCID:

Author	ORCID
Yang, Changhuei	0000-0001-8791-0354

Additional Information:

© 2016 Optical Society of America. Received 6 October 2015; revised 4 December 2015; accepted 26 December 2015; posted 5 January 2016 (Doc. ID 251465); published 1 February 2016. Funding: National Institute of Biomedical Imaging and Bioengineering (NIBIB) (1F31EB021153-01); National Institute of Neurological Disorders and Stroke (NINDS) (1U01NS090577-01); National Institutes of Health (NIH) (1DP2OD007307-01); Donna and Benjamin M. Rosen Bioengineering Center; GIST-Caltech (CG2012). J. B. acknowledges support from an NIH NRSA Predoctoral Fellowship and the Donna and Benjamin M. Rosen Bioengineering Center. The authors would also like to thank Dr. Cheng Xiao for his help in preparing the brain tissue slices.

Group:

Rosen Bioengineering Center

Funders:

Funding Agency	Grant Number
National Institute of Biomedical Imaging and Bioengineering	1F31EB021153-01
National Institute of Neurological Disorders and Stroke (NINDS)	1U01NS090577-01
NIH	1DP2OD007307-01
Donna and Benjamin M. Rosen Bioengineering Center	UNSPECIFIED
GIST-Caltech	CG2012
NIH Predoctoral Fellowship	UNSPECIFIED

Issue or Number:

Classification Code:

OCIS codes: (290.4210) Multiple scattering; (290.7050) Turbid media; (290.5820) Scattering measurements

PubMed Central ID:

PMC4783160

Record Number:

CaltechAUTHORS:20160218-123702274

Persistent URL:

https://resolver.caltech.edu/CaltechAUTHORS:20160218-123702274

Official Citation:

J. Brake, M. Jang, and C. Yang, "Analyzing the relationship between decorrelation time and tissue thickness in acute rat brain slices using multispeckle diffusing wave spectroscopy," J. Opt. Soc. Am. A 33, 270-275 (2016)

Usage Policy:

No commercial reproduction, distribution, display or performance rights in this work are provided.

ID Code:

64563

Collection:

CaltechAUTHORS

Deposited By:

Tony Diaz

Deposited On:

18 Feb 2016 23:26

Last Modified:

09 Mar 2020 13:19

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