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Immune Cell Identity: Perspective from a Palimpsest

Rothenberg, Ellen V. (2015) Immune Cell Identity: Perspective from a Palimpsest. Perspectives in Biology and Medicine, 58 (2). pp. 205-228. ISSN 1529-8795. PMCID PMC4747652. doi:10.1353/pbm.2015.0020.

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The immune system in mammals is composed of multiple different immune cell types that migrate through the body and are made continuously throughout life. Lymphocytes and myeloid cells interact with each other and depend upon each other, but each are highly diverse and specialized for different roles. Lymphocytes uniquely require developmentally programmed mutational changes in the genome itself for their maturation. Despite profound differences between their mechanisms of threat recognition and threat response, however, the developmental origins of lymphocytes and myeloid cells are interlinked, and important aspects of their response mechanisms remain shared. It is notable that the chain of logic toward our current understanding of the immune defense system over the past 50 years has been driven by strongly posited models that have led to crucial discoveries, even though these models ended up being partly wrong. The predictive strength of these models and their success as guides to incisive experimental research have illuminated the limits of each model’s explanatory scope, beyond which another model needed to assume the lead. This brief review describes how a succession of distinct paradigms has helped to clarify a sophisticated picture of immune cell generation and control.

Item Type:Article
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URLURL TypeDescription CentralArticle
Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 2016 by Johns Hopkins University Press. Only a brief sampling of references could be cited here, and they should be regarded as entry points to a massive literature. The author gratefully acknowledges the support of the Albert Billings Ruddock Professorship of Biology (California Institute of Technology) and grants to support the work of her laboratory from the U.S. Public Health Service, National Institutes of Health.
Funding AgencyGrant Number
Albert Billings Ruddock ProfessorshipUNSPECIFIED
Issue or Number:2
PubMed Central ID:PMC4747652
Record Number:CaltechAUTHORS:20160218-133043286
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64572
Deposited By: Tony Diaz
Deposited On:18 Feb 2016 21:37
Last Modified:10 Nov 2021 23:32

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