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Reconstruction of major fibers using 7T multi-shell Hybrid Diffusion Imaging in mice

Daianu, Madelaine and Jacobs, Russell E. and Zlokovic, Berislav V. and Montagne, Axel and Thompson, Paul M. (2015) Reconstruction of major fibers using 7T multi-shell Hybrid Diffusion Imaging in mice. In: 11th International Symposium on Medical Information Processing and Analysis. Proceedings of SPIE. No.9681. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 968109. ISBN 9781628419160. https://resolver.caltech.edu/CaltechAUTHORS:20160218-154112604

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Abstract

Diffusion weighted imaging (DWI) can reveal the orientation of the underlying fiber populations in the brain. High angular resolution diffusion imaging (HARDI) is increasingly used to better resolve the orientation and mixing of fibers. Here, we assessed the added value of multi-shell q-space sampling on the reconstruction of major fibers using mathematical frameworks from q-ball imaging (QBI) and generalized q-sampling imaging (GQI), as compared to diffusion tensor imaging (DTI). We scanned a healthy mouse brain using 7-Tesla 5-shell HARDI (b=1000, 3000, 4000, 8000, 12000 s/mm2), also known as hybrid diffusion imaging (HYDI). We found that QBI may provide greater reconstruction accuracy for major fibers, which improves with the addition of higher b-value shells, unlike GQI or DTI (as expected). Although QBI is a special case of GQI, the major fiber orientation in QBI was more closely related to the orientation in DTI, rather than GQI. HYDI can aid the clinical outcomes of research and especially – more advanced human and animal connectomics projects to map the brain’s neural pathways and networks.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/12.2207946DOIArticle
http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=2479314PublisherArticle
ORCID:
AuthorORCID
Jacobs, Russell E.0000-0002-1382-8486
Zlokovic, Berislav V.0000-0002-6802-8232
Additional Information:© 2015 SPIE.
Subject Keywords:DWI, multi-shell, HARDI, HYDI, mouse, QBI
Series Name:Proceedings of SPIE
Issue or Number:9681
Record Number:CaltechAUTHORS:20160218-154112604
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160218-154112604
Official Citation:Madelaine Daianu ; Russell E. Jacobs ; Berislav V. Zlokovic ; Axel Montagne ; Paul M. Thompson; Reconstruction of major fibers using 7T multi-shell Hybrid Diffusion Imaging in mice. Proc. SPIE 9681, 11th International Symposium on Medical Information Processing and Analysis, 968109 (December 22, 2015); doi:10.1117/12.2207946
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64595
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:18 Feb 2016 23:51
Last Modified:09 Mar 2020 13:19

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