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Long-Range DNA Charge Transport

Delaney, Sarah and Barton, Jacqueline K. (2003) Long-Range DNA Charge Transport. Journal of Organic Chemistry, 68 (17). pp. 6475-6483. ISSN 0022-3263. doi:10.1021/jo030095y.

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The stack of base pairs within double helical DNA has been shown to mediate charge transport reactions. Charge transport through DNA can result in chemistry at a distance, yielding oxidative DNA damage at a site remote from the bound oxidant. Since DNA charge transport chemistry depends on coupling within the stacked base pair array, this chemistry is remarkably sensitive to sequence-dependent DNA structure and dynamics. Here, we discuss different features of DNA charge transport chemistry, including applications as well as possible biological consequences and opportunities.

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Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 2003 American Chemical Society. Received March 17, 2003. Publication Date (Web): August 15, 2003. We are grateful to the NIH for financial support and to our many co-workers and collaborators for their contributions. J.K.B. also thanks the colleagues she has had who helped to inspire the exploration of this chemistry.
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Issue or Number:17
Record Number:CaltechAUTHORS:20160226-135927857
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Official Citation:Long-Range DNA Charge Transport Sarah Delaney and Jacqueline K. Barton The Journal of Organic Chemistry 2003 68 (17), 6475-6483 DOI: 10.1021/jo030095y
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64813
Deposited By: Ruth Sustaita
Deposited On:29 Feb 2016 18:36
Last Modified:10 Nov 2021 23:35

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