CaltechAUTHORS
  A Caltech Library Service

Conservation and divergence of BMP2/4 genes in the lamprey: expression and phylogenetic analysis suggest a single ancestral vertebrate gene

McCauley, David W. and Bronner-Fraser, Marianne (2004) Conservation and divergence of BMP2/4 genes in the lamprey: expression and phylogenetic analysis suggest a single ancestral vertebrate gene. Evolution & Development, 6 (6). pp. 411-422. ISSN 1520-541X. doi:10.1111/j.1525-142X.2004.04054.x. https://resolver.caltech.edu/CaltechAUTHORS:20160229-151057026

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20160229-151057026

Abstract

Bone morphogenetic protein (BMP) molecules are members of a large family of signaling molecules important in numerous developmental pathways throughout the metazoa. Single members of the BMP2/4 class have been found in invertebrates such as cnidarians, arthropods, nematodes, echinoderms, ascidians, and cephalochordates. In all vertebrates studied, there are at least two copies, BMP2 and BMP4, that play important roles in axial patterning, tissue specification, and organogenesis. The basal vertebrate, lamprey, diverged near the time of vertebrate origins and is useful for understanding the gene duplication events that led to the increased complexity of the vertebrate genome. We characterized the sequence and expression pattern of BMP2/4 class genes in the sea lamprey, Petromyzon marinus. We uncovered three genes that we named PmBMP2/4A, PmBMP2/4B, and PmBMP2/4C. Phylogenetic analysis indicates that PmBMP2/4A is closer than PmBMP2/4B or PmBMP2/4C in sequence identity to both BMP2 and BMP4 ofgnathostomes. The developmental expression pattern of PmBMP2/4A also more closely resembles the combined early expression patterns of gnathostome BMP2 and BMP4, whereas PmBMP2/4B and PmBMP2/4C appear to play roles only later in development. Cell labeling showed that the BMP-expressing cells in the branchial arches of lampreys are of neural crest origin. Taken together, our sequence and expression data support the duplication of BMP2/4 genes in the lamprey from a single ancestral vertebrate BMP2/4 gene.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1111/j.1525-142X.2004.04054.xDOIArticle
http://onlinelibrary.wiley.com/doi/10.1111/j.1525-142X.2004.04054.x/abstractPublisherArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© Blackwell Publishing. Article first published online: 27 Oct 2004. We thank Daniel Meulemans, Tatjana Sauka-Spengler, and two anonymous reviewers for helpful comments to improve this manuscript. We also thank Roger Bergstedt and the staff at Hammond Bay Biological Station for aid in collecting and rearing embryos, and Jim Langeland for embryonic cDNA libraries. Supported by NASA grant NAG2-1585 to M. B. F.
Funders:
Funding AgencyGrant Number
NASANAG2-1585
Issue or Number:6
DOI:10.1111/j.1525-142X.2004.04054.x
Record Number:CaltechAUTHORS:20160229-151057026
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160229-151057026
Official Citation:McCauley, D. W. and Bronner-Fraser, M. (2004), Conservation and divergence of BMP2/4 genes in the lamprey: expression and phylogenetic analysis suggest a single ancestral vertebrate gene. Evolution & Development, 6: 411–422. doi: 10.1111/j.1525-142X.2004.04054.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64873
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:29 Feb 2016 23:41
Last Modified:10 Nov 2021 23:36

Repository Staff Only: item control page