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Host-cell receptors for Sindbis virus

Strauss, J. H. and Wang, K.-S. and Schmaljohn, A. L. and Kuhn, R. J. and Strauss, E. G. (1994) Host-cell receptors for Sindbis virus. In: Positive-Strand RNA Viruses. Archives of Virology Supplementum. Vol.9. Springer , Vienna, Austria, pp. 473-484. ISBN 978-3-211-82522-8.

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Sindbis virus has a very wide host range, infecting many species of mosquitoes and other hematophagous insects and infecting many species of higher vertebrates. We have used two approaches to study host cell receptors used by Sindbis virus to enter cells. Antiidiotype antibodies to neutralizing antibodies directed against glycoprotein E2 of the virus identified a 63-kDa protein as a putative receptor in chicken cells. In a second approach, monoclonal antibodies identified a 67 kDa protein, believed to be a high affinity laminin receptor, as a putative receptor in mammalian cells and in mosquito cells. We conclude that the virus attains its very wide host range by two mechanisms. In one mechanism, the virus is able to use more than one protein as a receptor. In a second mechanism, the virus utilizes proteins as receptors that are highly conserved across the animal kingdom.

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Additional Information:© 1994 Springer-Verlag.
Series Name:Archives of Virology Supplementum
Record Number:CaltechAUTHORS:20160229-164441821
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64882
Deposited By: Donna Wrublewski
Deposited On:01 Mar 2016 01:00
Last Modified:12 May 2020 22:03

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