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Lunatic fringe causes expansion and increased neurogenesis of trunk neural tube and neural crest populations

De Bellard, Maria Elena and Barembaum, Meyer and Arman, Odette and Bronner-Fraser, Marianne (2007) Lunatic fringe causes expansion and increased neurogenesis of trunk neural tube and neural crest populations. Neuron Glia Biology, 3 (02). pp. 93-103. ISSN 1740-925X. doi:10.1017/S1740925X07000683. https://resolver.caltech.edu/CaltechAUTHORS:20160301-070210885

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Abstract

Both neurons and glia of the PNS are derived from the neural crest. In this study, we have examined the potential function of lunatic fringe in neural tube and trunk neural crest development by gain-of-function analysis during early stages of nervous system formation. Normally lunatic fringe is expressed in three broad bands within the neural tube, and is most prominent in the dorsal neural tube containing neural crest precursors. Using retrovirally-mediated gene transfer, we find that excess lunatic fringe in the neural tube increases the numbers of neural crest cells in the migratory stream via an apparent increase in cell proliferation. In addition, lunatic fringe augments the numbers of neurons and upregulates Delta-1 expression. The results indicate that, by modulating Notch/Delta signaling, lunatic fringe not only increases cell division of neural crest precursors, but also increases the numbers of neurons in the trunk neural crest.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1017/S1740925X07000683DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293300/#!po=2.77778PubMed CentralArticle
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1740936&fulltextType=RA&fileId=S1740925X07000683PublisherArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2007 Cambridge University Press. Received November 14 2007. Accepted November 16 2007. Published online: 06 February 2008. Special thanks to Gustavo Gomez and Ruel Velazco for their expert technical assistance and to Cindy Malone for help editing this manuscript. We thank Vivian Lee, Yun Kee and Christine Nelleman for useful discussions and Ed Laufer for providing the RCAS virus used in these experiments. This work was supported in part by a postdoctoral fellowship to MEdB from the National Multiple Sclerosis Society (FA 1383-A-1) and NIH-MBRS SCORE-5S06GM048680-13; and by a USPHS NS36585 and DE13223 to MBF.
Funders:
Funding AgencyGrant Number
National Multiple Sclerosis SocietyFA 1383-A-1
NIHSCORE-5S06GM048680-13
NIHNS36585
NIHDE13223
Subject Keywords:neural crest; lunatic fringe; notch; cell division
Issue or Number:02
DOI:10.1017/S1740925X07000683
Record Number:CaltechAUTHORS:20160301-070210885
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160301-070210885
Official Citation:Maria Elena De Bellard, Meyer Barembaum, Odette Arman and Marianne Bronner-Fraser (2007). Lunatic fringe causes expansion and increased neurogenesis of trunk neural tube and neural crest populations. Neuron Glia Biology, 3, pp 93-103. doi:10.1017/S1740925X07000683.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64885
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:01 Mar 2016 23:53
Last Modified:10 Nov 2021 23:36

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