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Magnetic Resonance Imaging of Functional Anatomy: Use for Small Animal Epilepsy Models

Obenaus, Andre and Jacobs, Russell E. (2007) Magnetic Resonance Imaging of Functional Anatomy: Use for Small Animal Epilepsy Models. Epilepsia, 48 (s4). pp. 11-17. ISSN 0013-9580. doi:10.1111/j.1528-1167.2007.01237.x.

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Neuroimaging has greatly assisted the diagnosis and treatment of epilepsy. Volumetric analysis, diffusion-weighted imaging, and other magnetic resonance imaging (MRI) modalities provide a clear picture of altered anatomical structures in both focal and nonfocal disease. More recently, advances in novel imaging methodologies have provided unique insights into this disease. Two examples include manganese-enhanced MRI (MEMRI) and diffusion tensor imaging (DTI). MEMRI involves injection of MnCl_2 to evaluate neuronal activity where it is actively transported. Areas of neuronal hyperactivity are expected to have altered uptake and transport. Mapping of activation along preferential uptake pathways can be confirmed by T_1-weighted imaging. DTI uses the intrinsic preferential mobility of water movement along axonal pathways to map anatomical regions. DTI has been used to investigate white matter disease and is now being applied to clinical and, to a lesser extent, animal investigations of seizure disorders. These two diverse MRI methods can be applied to animal models to provide important information about the functional status of anatomical regions that may be altered by epilepsy.

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Jacobs, Russell E.0000-0002-1382-8486
Additional Information:© 2007 Blackwell Publishing, Inc. International League Against Epilepsy. Article first published online: 28 Aug 2007. The authors acknowledge Dr. Sheng-Kwei Song for a critical review of the manuscript and for providing Fig. 2. The Non-Invasive Imaging Laboratory is supported in part by a NASA Cooperative Agreement NCC9-149 to Loma Linda University. The Biological Imaging Center is supported by the Beckman Institute at Caltech.
Funding AgencyGrant Number
Caltech Beckman InstituteUNSPECIFIED
Subject Keywords:Diffusion tensor; Manganese; Epilepsy; Tract tracing; Rat; MRI
Issue or Number:s4
Record Number:CaltechAUTHORS:20160301-072250321
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Official Citation:Obenaus, A. and Jacobs, R. E. (2007), Magnetic Resonance Imaging of Functional Anatomy: Use for Small Animal Epilepsy Models. Epilepsia, 48: 11–17. doi: 10.1111/j.1528-1167.2007.01237.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64886
Deposited By: Ruth Sustaita
Deposited On:01 Mar 2016 23:48
Last Modified:10 Nov 2021 23:36

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