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Multimodal, Multidimensional Models of Mouse Brain

MacKenzie-Graham, Allan J. and Lee, Erh-Fang and Dinov, Ivo D. and Yuan, Heng and Jacobs, Russell E. and Toga, Arthur W. (2007) Multimodal, Multidimensional Models of Mouse Brain. Epilepsia, 48 (s4). pp. 75-81. ISSN 0013-9580. PMCID PMC3192853. doi:10.1111/j.1528-1167.2007.01244.x.

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Naturally occurring mutants and genetically manipulated strains of mice are widely used to model a variety of human diseases. Atlases are an invaluable aid in understanding the impact of such manipulations by providing a standard for comparison and to facilitate the integration of anatomic, genetic, and physiologic observations from multiple subjects and experiments. We have developed digital atlases of the C57BL/6J mouse brain (adult and neonate) as comprehensive frameworks for storing and accessing the myriad types of information about the mouse brain. Along with raw and annotated images, these contain database management systems and a set of tools for comparing information from different techniques and different animals. Each atlas establishes a canonical representation of the mouse brain and provides the tools for the manipulation and analysis of new data. We describe both these atlases and discuss how they may be put to use in organizing and analyzing data from mouse models of epilepsy.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Jacobs, Russell E.0000-0002-1382-8486
Additional Information:© 2007 Blackwell Publishing, Inc.International League Against Epilepsy. Article first published online: 28 Aug 2007. This work was generously supported by research grants from the National Institute of Mental Health (5 RO1 MH61223) and the National Institutes of Health/National Center for Research Resources (P41 RR13642). The authors also wish to acknowledge their deep appreciation to the members of the Laboratory of Neuro Imaging. We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. None of the authors have any conflicts of interest in the publication of this work.
Funding AgencyGrant Number
National Institute of Mental Health (NIMH)5 RO1 MH61223
National Center for Research Resources (NCRR)P41 RR13642
Issue or Number:s4
PubMed Central ID:PMC3192853
Record Number:CaltechAUTHORS:20160301-072250687
Persistent URL:
Official Citation:MacKenzie-Graham, A. J., Lee, E.-F., Dinov, I. D., Yuan, H., Jacobs, R. E. and Toga, A. W. (2007), Multimodal, Multidimensional Models of Mouse Brain. Epilepsia, 48: 75–81. doi: 10.1111/j.1528-1167.2007.01244.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64887
Deposited By: Ruth Sustaita
Deposited On:01 Mar 2016 23:51
Last Modified:10 Nov 2021 23:36

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