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Intracellular Transport Dynamics of Endosomes Containing DNA Polyplexes along the Microtubule Network

Kulkarni, Rajan P. and Castelino, Kenneth and Majumdar, Arun and Fraser, Scott E. (2006) Intracellular Transport Dynamics of Endosomes Containing DNA Polyplexes along the Microtubule Network. Biophysical Journal, 90 (5). L42-L44. ISSN 0006-3495. PMCID PMC1367335. http://resolver.caltech.edu/CaltechAUTHORS:20160303-080012692

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Abstract

We have explored the transport of DNA polyplexes enclosed in endosomes within the cellular environment by multiple particle tracking (MPT). The polyplex-loaded endosomes demonstrate enhanced diffusion at short timescales (t < 7 s) with their mean-square displacement (MSD) 〈Δx(t)^2〉 scaling as t^(1.25). For longer time intervals they exhibit subdiffusive transport and have an MSD scaling as t^(0.7). This crossover from an enhanced diffusion to a subdiffusive regime can be explained by considering the action of motor proteins that actively transport these endosomes along the cellular microtubule network and the thermal bending modes of the microtubule network itself.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1529/biophysj.105.077941DOIArticle
http://www.sciencedirect.com/science/article/pii/S0006349506723372PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1367335/PubMed CentralArticle
ORCID:
AuthorORCID
Fraser, Scott E.0000-0002-5739-4026
Additional Information:© 2006 by the Biophysical Society. Received for publication 16 November 2005 and in final form 4 January 2006.
PubMed Central ID:PMC1367335
Record Number:CaltechAUTHORS:20160303-080012692
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160303-080012692
Official Citation:Rajan P. Kulkarni, Kenneth Castelino, Arun Majumdar, Scott E. Fraser, Intracellular Transport Dynamics of Endosomes Containing DNA Polyplexes along the Microtubule Network, Biophysical Journal, Volume 90, Issue 5, 1 March 2006, Pages L42-L44, ISSN 0006-3495, http://dx.doi.org/10.1529/biophysj.105.077941. (http://www.sciencedirect.com/science/article/pii/S0006349506723372)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:64982
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:04 Mar 2016 22:29
Last Modified:04 Mar 2016 22:29

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