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Application of Ionic Liquids in Pot-in-Pot Reactions

Çınar, Simge and Schulz, Michael D. and Oyola-Reynoso, Stephanie and Bwambok, David and Gathiaka, Symon and Thuo, Martin (2016) Application of Ionic Liquids in Pot-in-Pot Reactions. Molecules, 21 (3). Art. No. 272. ISSN 1420-3049. PMCID PMC6273955. doi:10.3390/molecules21030272. https://resolver.caltech.edu/CaltechAUTHORS:20160304-160900578

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Abstract

Pot-in-pot reactions are designed such that two reaction media (solvents, catalysts and reagents) are isolated from each other by a polymeric membrane similar to matryoshka dolls (Russian nesting dolls). The first reaction is allowed to progress to completion before triggering the second reaction in which all necessary solvents, reactants, or catalysts are placed except for the starting reagent for the target reaction. With the appropriate trigger, in most cases unidirectional flux, the product of the first reaction is introduced to the second medium allowing a second transformation in the same glass reaction pot—albeit separated by a polymeric membrane. The basis of these reaction systems is the controlled selective flux of one reagent over the other components of the first reaction while maintaining steady-state catalyst concentration in the first “pot”. The use of ionic liquids as tools to control chemical potential across the polymeric membranes making the first pot is discussed based on standard diffusion models—Fickian and Payne’s models. Besides chemical potential, use of ionic liquids as delivery agent for a small amount of a solvent that slightly swells the polymeric membrane, hence increasing flux, is highlighted. This review highlights the critical role ionic liquids play in site-isolation of multiple catalyzed reactions in a standard pot-in-pot reaction.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.3390/molecules21030272DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273955PubMed CentralArticle
ORCID:
AuthorORCID
Schulz, Michael D.0000-0001-8499-6025
Thuo, Martin0000-0003-3448-8027
Additional Information:© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). Received: 20 November 2015; Accepted: 18 February 2016; Published: 26 February 2016. (This article belongs to the Special Issue Ionic Liquids in Organic Synthesis) This work was supported by the Iowa State University through start-up funds. M.T. was partially supported by a Black and Veatch faculty fellowship, S.O.-R. was partially supported by a GMAP fellowship from Iowa State University.
Funders:
Funding AgencyGrant Number
Iowa State UniversityUNSPECIFIED
Black and Veatch Faculty FellowshipUNSPECIFIED
Subject Keywords:Pot-in-pot Reactions; Unidirectional Flux; Cascade Reactions; Membrane Separation; Multi-step Synthesis
Issue or Number:3
PubMed Central ID:PMC6273955
DOI:10.3390/molecules21030272
Record Number:CaltechAUTHORS:20160304-160900578
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160304-160900578
Official Citation:Çınar S, Schulz MD, Oyola-Reynoso S, Bwambok DK, Gathiaka SM, Thuo M. Application of Ionic Liquids in Pot-in-Pot Reactions. Molecules. 2016; 21(3):272.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65089
Collection:CaltechAUTHORS
Deposited By: Melissa Ray
Deposited On:05 Mar 2016 00:43
Last Modified:06 May 2022 16:56

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