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Method for the quantification of rupture probability in soft collagenous tissues

Balzani, D. and Schmidt, T. and Ortiz, M. (2017) Method for the quantification of rupture probability in soft collagenous tissues. International Journal for Numerical Methods in Biomedical Engineering, 33 (1). Art. No. e02781. ISSN 2040-7939.

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A computational method is presented for the assessment of rupture probabilities in soft collagenous tissues. This may in particular be important for the quantitative analysis of medical diseases such as atherosclerotic arteries or abdominal aortic aneurysms, where an unidentified rupture has in most cases fatal consequences. The method is based on the numerical minimization and maximization of probabilities of failure, which arise from random input quantities, for example, tissue properties. Instead of assuming probability distributions for these quantities, which are typically unknown especially for soft collagenous tissues, only restricted knowledge of these distributions is taken into account. Given this limited statistical input data, the minimized/maximized probabilities represent optimal bounds on the rupture probability, which enable a quantitative estimation of potential risks of performing or not performing medical treatment. Although easily extendable to all kinds of mechanical rupture criteria, the approach presented here incorporates stretch-based and damage-based criteria. These are evaluated based on numerical simulations of loaded tissues, where continuum mechanical material formulations are considered, which capture the supra-physiological behavior of soft collagenous tissues. Numerical examples are provided demonstrating the applicability of the method in an overstretched atherosclerotic artery.

Item Type:Article
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Ortiz, M.0000-0001-5877-4824
Additional Information:© 2016 John Wiley & Sons, Ltd. Received 24 August 2015; Revised 29 January 2016; Accepted 22 February 2016. Financial support of the German Science Foundation (DFG) under the project no. BA2823/5-3 is highly acknowledged. The author D. Balzani additionally thanks the DFG for funding in the context of the Institutional Strategy ‘The Synergetic University’ at TU Dresden, as part of the Excellence Initiative. Furthermore, scientific discussions with Mike McKerns and Tim Sullivan are appreciated.
Funding AgencyGrant Number
Deutsche Forschungsgemeinschaft (DFG)BA2823/5-3
Subject Keywords:cardiovascular system; atherosclerotic arteries; damage; softening; mechanical modeling; optimal uncertainty quantification
Issue or Number:1
Record Number:CaltechAUTHORS:20160307-085012921
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Official Citation:Balzani, D., Schmidt, T., and Ortiz, M. (2017) Method for the quantification of rupture probability in soft collagenous tissues. Int. J. Numer. Meth. Biomed. Engng., 33: e02781. doi: 10.1002/cnm.2781
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65100
Deposited By: Tony Diaz
Deposited On:08 Mar 2016 19:00
Last Modified:22 Apr 2020 19:10

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