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Glycan Engineering for Cell and Developmental Biology

Griffin, Matthew E. and Hsieh-Wilson, Linda C. (2016) Glycan Engineering for Cell and Developmental Biology. Cell Chemical Biology, 23 (1). pp. 108-121. ISSN 2451-9456. PMCID PMC4857608. doi:10.1016/j.chembiol.2015.12.007.

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Cell-surface glycans are a diverse class of macromolecules that participate in many key biological processes, including cell-cell communication, development, and disease progression. Thus, the ability to modulate the structures of glycans on cell surfaces provides a powerful means not only to understand fundamental processes but also to direct activity and elicit desired cellular responses. Here, we describe methods to sculpt glycans on cell surfaces and highlight recent successes in which artificially engineered glycans have been employed to control biological outcomes such as the immune response and stem cell fate.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Griffin, Matthew E.0000-0001-9549-4418
Hsieh-Wilson, Linda C.0000-0001-5661-1714
Additional Information:© 2016 Elsevier Ltd. This research was supported by the NIH (R01-GM093627 and R01-GM084724) and a National Science Foundation Graduate Research Fellowship (DGE-1144469).
Funding AgencyGrant Number
NSF Graduate Research FellowshipDGE-1144469
Issue or Number:1
PubMed Central ID:PMC4857608
Record Number:CaltechAUTHORS:20160307-093656769
Persistent URL:
Official Citation:Matthew E. Griffin, Linda C. Hsieh-Wilson, Glycan Engineering for Cell and Developmental Biology, Cell Chemical Biology, Volume 23, Issue 1, 21 January 2016, Pages 108-121, ISSN 2451-9456,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65104
Deposited By: Tony Diaz
Deposited On:08 Mar 2016 18:52
Last Modified:12 May 2022 18:53

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