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Effects of Mesodermal Tissues on Avian Neural Crest Cell Migration

Bronner-Fraser, Marianne and Stern, Claudio (1991) Effects of Mesodermal Tissues on Avian Neural Crest Cell Migration. Developmental Biology, 143 (2). pp. 213-217. ISSN 0012-1606. doi:10.1016/0012-1606(91)90071-A.

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We have used microsurgical techniques to investigate the effects of embryonic mesodermal tissues on the pattern of chick neural crest cell migration in the trunk. Segmental plate or lateral plate mesenchyme was transplanted into regions encountered by neural crest cells. We found that neural crest cells are able to migrate through lateral plate mesenchyme but not through segmental plate tissue until this tissue differentiates into a sclerotome. After this stage, segmental migration is controlled by the subdivision of the sclerotome into a rostral and a caudal half: when the rostrocaudal orientation of the sclerotomes is reversed by rotating the segmental plate 180° about its rostrocaudal axis, neural crest cells migrate through the portion of the sclerotome that was originally rostral.

Item Type:Article
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URLURL TypeDescription
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 1991 Academic Press, Inc. Accepted 9 October 1990. This study was funded by USPHS Grant HD 15527 and a grant from the Muscular Dystrophy Association to M.B.F. and by a travel grant from the Wellcome Trust to C.D.S. M.B.F. is a Sloan Research Fellow.
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)HD-15527
Muscular Dystrophy AssociationUNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
Issue or Number:2
Record Number:CaltechAUTHORS:20160307-141030790
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Official Citation:Marianne Bronner-Fraser, Claudio Stern, Effects of mesodermal tissues on avian neural crest cell migration, Developmental Biology, Volume 143, Issue 2, February 1991, Pages 213-217, ISSN 0012-1606, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65138
Deposited By: Ruth Sustaita
Deposited On:14 Mar 2016 21:53
Last Modified:10 Nov 2021 23:40

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