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Dynamic Changes in Optic Fiber Terminal Arbors Lead to Retinotopic Map Formation: An In Vivo Confocal Microscopic Study

O'Rourke, Nancy A. and Fraser, Scott E. (1990) Dynamic Changes in Optic Fiber Terminal Arbors Lead to Retinotopic Map Formation: An In Vivo Confocal Microscopic Study. Neuron, 5 (2). pp. 159-171. ISSN 0896-6273. https://resolver.caltech.edu/CaltechAUTHORS:20160308-084749977

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Abstract

Dynamic remodeling of retinal ganglion cell terminal arbors has been proposed to contribute to formation of the topographically ordered retinotectal projection. To test this directly, the growth of individual terminal arbors was observed in live X. laevis tadpoles using a confocal microscope to visualize their complex three-dimensional structure. During initial development, nasal and temporal retinal arbors covered overlapping tectal areas. Despite subsequent remodeling, the dimensions and positions of the temporal arbors remained relatively stable. In contrast, the nasal arbors grew caudally, as they extended caudal branches and retracted rostral branches. These results suggest that differences in the remodeling of the nasal and temporal arbors lead to the emergence of retino-topography along the rostrocaudal axis of the tectum. All the terminal arbors were dynamic, including those with stable dimensions, suggesting that continual remodeling of arbors may be a universal feature of neuronal projections.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/0896-6273(90)90306-ZDOIArticle
http://www.sciencedirect.com/science/article/pii/089662739090306ZPublisherArticle
ORCID:
AuthorORCID
Fraser, Scott E.0000-0002-5377-0223
Additional Information:© 1990 Cell Press. Received 5 January 1990, Revised 20 April 1990. We thank Frank Truong for help with data analysis and Scott Burgan for processing the photographs. Statistical assistance was generously provided by Dr. Howard G. Tucker, who advised us on the appropriate tests to use, and Cheryl A. Arthur, who carried out some of the tests on our data. Dr. Tucker and Ms. Arthur are both affiliated with the Department of Mathematics, University of California, Irvine. We are also grateful for helpful comments on the manuscript from Drs. Katy Lynch, Jes Stollberg, and Rick Wetts. This research was supported by grants from the National Science Foundation (BNS08356) and the National Institutes of Health (N52521) and by a gift from the Monsanto Corporation.
Funders:
Funding AgencyGrant Number
NSFBNS08356
NIHN52521
Monsanto CorporationUNSPECIFIED
Issue or Number:2
Record Number:CaltechAUTHORS:20160308-084749977
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160308-084749977
Official Citation:Nancy A. O'Rourke, Scott E. Fraser, Dynamic changes in optic fiber terminal arbors lead to retinotopic map formation: An in vivo confocal microscopic study, Neuron, Volume 5, Issue 2, August 1990, Pages 159-171, ISSN 0896-6273, http://dx.doi.org/10.1016/0896-6273(90)90306-Z. (http://www.sciencedirect.com/science/article/pii/089662739090306Z)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65182
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:08 Mar 2016 19:13
Last Modified:03 Oct 2019 09:44

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