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Magnetic resonance microscopy of iron in the basal forebrain cholinergic structures of the aged mouse lemur

Gilissen, Emmanuel P. and Jacobs, Russell E. and Allman, John M. (1999) Magnetic resonance microscopy of iron in the basal forebrain cholinergic structures of the aged mouse lemur. Journal of the Neurological Sciences, 168 (1). pp. 21-27. ISSN 0022-510X. doi:10.1016/S0022-510X(99)00162-8.

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Increased non-heme iron levels in the brain of Alzheimer’s disease (AD) patients are higher than the levels observed in age matched normal subjects. Iron level in structures that are highly relevant for AD, such as the basal forebrain, can be detected post mortem with histochemistry. Because of the small size of these structures, in vivo MR detection is very difficult at conventional field magnets (1.5 and 4 T). In this study, we observed iron deposits with histochemistry and MR microscopy at 11.7 T in the brain of the mouse lemur, a strepsirhine primate which is the only known animal model of aging presenting both senile plaques and neurofibrillary degeneration. We also examined a related species, the dwarf lemur. Iron distribution in aged animals (8 to 15 years old) agrees with previous findings in humans. In addition, the high iron levels of the globus pallidus is paralleled by a comparable contrast in basal forebrain cholinergic structures. Because of the enhancement of iron-dependent contrast with increasing field strength, microscopic magnetic resonance imaging of the mouse lemur appears to be an ideal model system for studying in vivo iron changes in the basal forebrain in relation to aging and neurodegeneration.

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Jacobs, Russell E.0000-0002-1382-8486
Additional Information:© 1999 Elsevier Science B.V. Received 15 May 1998; received in revised form 24 June 1999; accepted 29 June 1999. We thank Dr George Bartzokis, West Los Angeles VA Medical Center, and Dr Marc Dhenain, California Institute of Technology, for helpful suggestions, Dr Kenneth Glander, Duke Primate Center, for providing the mouse lemur brains, and Dr Pratik Ghosh for his help during the initial phases of this work. One anonymous reviewer made very constructive comments. Supported by the von Humboldt and the Del Webb Foundations (EG). Additional funding was provided by the Human Brain Project with contributions from the National Institute on Drug Abuse, the National Institute of Mental Health, and the National Science Foundation.
Funding AgencyGrant Number
Alexander von Humboldt FoundationUNSPECIFIED
Del Webb FoundationUNSPECIFIED
Human Brain ProjectUNSPECIFIED
National Institute on Drug AbuseUNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
Subject Keywords:Basal forebrain; Iron; Magnetic resonance imaging; Animal model; Mouse lemur; Aging; Alzheimer’s disease
Issue or Number:1
Record Number:CaltechAUTHORS:20160308-140930564
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Official Citation:Emmanuel P Gilissen, Russell E Jacobs, John M Allman, Magnetic resonance microscopy of iron in the basal forebrain cholinergic structures of the aged mouse lemur, Journal of the Neurological Sciences, Volume 168, Issue 1, 15 September 1999, Pages 21-27, ISSN 0022-510X, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65217
Deposited By: Tony Diaz
Deposited On:10 Mar 2016 20:20
Last Modified:10 Nov 2021 23:41

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