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Statistical distribution of hydrophobic residues along the length of protein chains. Implications for protein folding and evolution

White, Stephen H. and Jacobs, Russell E. (1990) Statistical distribution of hydrophobic residues along the length of protein chains. Implications for protein folding and evolution. Biophysical Journal, 57 (4). pp. 911-921. ISSN 0006-3495. PMCID PMC1280792. https://resolver.caltech.edu/CaltechAUTHORS:20160310-122843225

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Abstract

We consider in this paper the statistical distribution of hydrophobic residues along the length of protein chains. For this purpose we used a binary hydrophobicity scale which assigns hydrophobic residues a value of one and non-hydrophobes a value of zero. The resulting binary sequences are tested for randomness using the standard run test. For the majority of the 5,247 proteins examined, the distribution of hydrophobic residues along a sequence cannot be distinguished from that expected for a random distribution. This suggests that (a) functional proteins may have originated from random sequences, (b) the folding of proteins into compact structures may be much more permissive with less sequence specificity than previously thought, and (c) the clusters of hydrophobic residues along chains which are revealed by hydrophobicity plots are a natural consequence of a random distribution and can be conveniently described by binomial statistics.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0006-3495(90)82611-4DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280792/PubMed CentralArticle
http://www.cell.com/biophysj/abstract/S0006-3495%2890%2982611-4PublisherArticle
ORCID:
AuthorORCID
Jacobs, Russell E.0000-0002-1382-8486
Additional Information:© 1990 Biophysical Society. Published by Elsevier Inc. Received for publication 11 September 1989 and in final form 10 January 1990. This work was supported by a grant from the National Science Foundation (DMB-8807431 ). R. E. Jacobs is an Established Investigator of the American Heart Association.
Funders:
Funding AgencyGrant Number
NSFDMB-8807431
American Heart AssociationUNSPECIFIED
Issue or Number:4
PubMed Central ID:PMC1280792
Record Number:CaltechAUTHORS:20160310-122843225
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160310-122843225
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65261
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:10 Mar 2016 20:57
Last Modified:03 Oct 2019 09:45

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