White, Stephen H. and Jacobs, Russell E. (1990) Statistical distribution of hydrophobic residues along the length of protein chains. Implications for protein folding and evolution. Biophysical Journal, 57 (4). pp. 911-921. ISSN 0006-3495. PMCID PMC1280792. doi:10.1016/S0006-3495(90)82611-4. https://resolver.caltech.edu/CaltechAUTHORS:20160310-122843225
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Abstract
We consider in this paper the statistical distribution of hydrophobic residues along the length of protein chains. For this purpose we used a binary hydrophobicity scale which assigns hydrophobic residues a value of one and non-hydrophobes a value of zero. The resulting binary sequences are tested for randomness using the standard run test. For the majority of the 5,247 proteins examined, the distribution of hydrophobic residues along a sequence cannot be distinguished from that expected for a random distribution. This suggests that (a) functional proteins may have originated from random sequences, (b) the folding of proteins into compact structures may be much more permissive with less sequence specificity than previously thought, and (c) the clusters of hydrophobic residues along chains which are revealed by hydrophobicity plots are a natural consequence of a random distribution and can be conveniently described by binomial statistics.
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Additional Information: | © 1990 Biophysical Society. Published by Elsevier Inc. Received for publication 11 September 1989 and in final form 10 January 1990. This work was supported by a grant from the National Science Foundation (DMB-8807431 ). R. E. Jacobs is an Established Investigator of the American Heart Association. | ||||||||||||
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Issue or Number: | 4 | ||||||||||||
PubMed Central ID: | PMC1280792 | ||||||||||||
DOI: | 10.1016/S0006-3495(90)82611-4 | ||||||||||||
Record Number: | CaltechAUTHORS:20160310-122843225 | ||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160310-122843225 | ||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
ID Code: | 65261 | ||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||
Deposited By: | Ruth Sustaita | ||||||||||||
Deposited On: | 10 Mar 2016 20:57 | ||||||||||||
Last Modified: | 10 Nov 2021 23:42 |
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