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Pattern formation and developmental mechanisms: The cell biological basis of inductive signaling

Bronner-Fraser, Marianne and Sternberg, Paul W. (2000) Pattern formation and developmental mechanisms: The cell biological basis of inductive signaling. Current Opinion in Genetics and Development, 10 (4). pp. 347-349. ISSN 0959-437X. https://resolver.caltech.edu/CaltechAUTHORS:20160311-065659955

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Abstract

A central issue in developmental biology is how a complex organism arises from a single cell. In both plant and animal development, this occurs by a combination of intrinsic information within cells as well as signals transmitted between cells that result in proper patterning of the embryo. Because of the central role of cell communication, intercellular signaling and signal transduction is an important consideration for understanding development as well as the interplay of signaling and transcription. The transcriptional state of the cell depends upon its prior history and the signals it receives. In turn, the signals produced by a cell and its ability to respond to signals are programmed to a large extent by its transcriptional state. The particular wiring of these signals→transcription→signals circuits determines how cells communicate to specify their fates in particular patterns.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0959-437X(00)00094-0DOIArticle
http://www.sciencedirect.com/science/article/pii/S0959437X00000940PublisherArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 2000 Elsevier Science Ltd. Available online 14 July 2000.
Issue or Number:4
Record Number:CaltechAUTHORS:20160311-065659955
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160311-065659955
Official Citation:Marianne Bronner-Fraser, Paul W Sternberg, Pattern formation and developmental mechanisms: The cell biological basis of inductive signaling, Current Opinion in Genetics & Development, Volume 10, Issue 4, 1 August 2000, Pages 347-349, ISSN 0959-437X, http://dx.doi.org/10.1016/S0959-437X(00)00094-0. (http://www.sciencedirect.com/science/article/pii/S0959437X00000940)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65287
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:14 Mar 2016 20:37
Last Modified:03 Oct 2019 09:45

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