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Dorsal and Ventral Cell Types Can Arise from Common Neural Tube Progenitors

Artinger, Kristin B. and Fraser, Scott and Bronner-Fraser, Marianne (1995) Dorsal and Ventral Cell Types Can Arise from Common Neural Tube Progenitors. Developmental Biology, 172 (2). pp. 591-601. ISSN 0012-1606. doi:10.1006/dbio.1995.8038.

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To challenge the developmental potential of dorsal neural tube cells and test whether single neuroepithelial cells can give rise to the full range of neural tube derivatives, we grafted a notochord lateral to the closing neural folds. This results in juxtaposition of dorsal and ventral cell types, by inducing floor plate cells and motor neurons dorsally. Clonal analysis with the vital dye lysinated rhodamine dextran showed that both “dorsal” and “ventral” neural tube derivatives can arise from a single precursor. Cells as diverse as sensory ganglion cells, presumptive pigment cells, roof plate cells, motor neurons, and floor plate cells were observed in the same clone. The presence of such diversity within single clones indicates that the responses to dorsal and ventral signals are not mutually exclusive; even in the early neural tube, neuroepithelial cells are not restricted to form only dorsal or ventral neural tube derivatives.

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Fraser, Scott0000-0002-5377-0223
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 1995 Academic Press, Inc. Received for publication 30 June 1995, Accepted 22 August 1995. We thank Drs. A. Collazo, M. Dickinson, C. Krull, J. Sechrist, M. Selleck, and J. Shih for helpful comments on the manuscript, Drs. S. Ruffins and M. Selleck for help with image analysis, and B. Metscher and S. Bryant for help with the polyester wax protocol. We gratefully acknowledge the generous gifts of antibodies from a number of colleagues: Drs. H. Tanaka and T. Yamada for the FP-1 antibody, Dr. Virginia Lee for the neurofilament antibody, and Drs. Ulf Eriksson and Malcom Maden for the anti-CRABP antibodies. This work was supported by USPHS HD-25138 and MH-49176.
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National Institute of Mental Health (NIMH)MH-49176
Issue or Number:2
Record Number:CaltechAUTHORS:20160311-070433737
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Official Citation:Kristin B. Artinger, Scott Fraser, Marianne Bronner-Fraser, Dorsal and Ventral Cell Types Can Arise from Common Neural Tube Progenitors, Developmental Biology, Volume 172, Issue 2, December 1995, Pages 591-601, ISSN 0012-1606, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65288
Deposited By: Ruth Sustaita
Deposited On:14 Mar 2016 20:34
Last Modified:10 Nov 2021 23:42

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