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Electrophysiological mapping of rat sensorimotor lumbosacral spinal networks after complete paralysis

Gad, Parag and Roy, Roland R. and Choe, Jaehoon and Zhong, Hui and Nandra, Mandheeraj Singh and Tai, Yu-Chong and Gerasimenko, Yury and Edgerton, V. Reggie (2015) Electrophysiological mapping of rat sensorimotor lumbosacral spinal networks after complete paralysis. In: Sensorimotor Rehabilitation - At the Crossroads of Basic and Clinical Sciences. Progress in brain research. No.218. Elsevier , Amsterdam, pp. 199-212. ISBN 9780444635679. PMCID PMC4512743. http://resolver.caltech.edu/CaltechAUTHORS:20160311-084618722

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Abstract

Stimulation of the spinal cord has been shown to have great potential for improving function after motor deficits caused by injury or pathological conditions. Using a wide range of animal models, many studies have shown that stimulation applied to the neural networks intrinsic to the spinal cord can result in a dramatic improvement of motor ability, even allowing an animal to step and stand after a complete spinal cord transection. Clinical use of this technology, however, has been slow to develop due to the invasive nature of the implantation procedures and the difficulty of ascertaining specific sites of stimulation that would provide optimal amelioration of the motor deficits. Moreover, the development of tools available to control precise stimulation chronically via biocompatible electrodes has been limited. In this chapter, we outline the use of a multisite electrode array in the spinal rat model to identify and stimulate specific sites of the spinal cord to produce discrete motor behaviors in spinal rats. The results demonstrate that spinal rats can stand and step when the spinal cord is stimulated tonically via electrodes located at specific sites on the spinal cord. The quality of stepping and standing was dependent on the location of the electrodes on the spinal cord, the specific stimulation parameters, and the orientation of the cathode and anode. The spinal motor evoked potentials in selected muscles during standing and stepping are shown to be critical tools to study selective activation of interneuronal circuits via responses of varying latencies. The present results provide further evidence that the assessment of functional networks in the background of behaviorally relevant functional states is likely to be a physiological tool of considerable importance in developing strategies to facilitate recovery of motor function after a number of neuromotor disorders.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/bs.pbr.2015.01.005 DOIArticle
http://www.sciencedirect.com/science/article/pii/S0079612315000060PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512743/PubMed CentralArticle
ORCID:
AuthorORCID
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2015 Elsevier B.V. P.G., R.R.R., Y.G. and V.R.E. designed the experiments. M.N. and Y.T. designed and fabricated the implant. R.R.R. and H.Z. performed all the surgeries. P.G. and J.C. performed the experiments. P.G. analyzed the data. P.G., Y. G., R.R.R. and V.R.E. wrote the chapter. All authors approved the final version of the chapter.
Subject Keywords:spinal cord epidural stimulation; spinal motor evoked potentials; electrode array; electric enabling motor control; locomotion; neurorehabilitation
PubMed Central ID:PMC4512743
Record Number:CaltechAUTHORS:20160311-084618722
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160311-084618722
Official Citation:Parag Gad, Roland R. Roy, Jaehoon Choe, Hui Zhong, Mandheeraj Singh Nandra, Yu-Chong Tai, Yury Gerasimenko, V. Reggie Edgerton, Chapter 9 - Electrophysiological mapping of rat sensorimotor lumbosacral spinal networks after complete paralysis☆, In: Numa Dancause, Sylvie Nadeau and Serge Rossignol, Editor(s), Progress in Brain Research, Elsevier, 2015, Volume 218, Pages 199-212, ISSN 0079-6123, ISBN 9780444635655, http://dx.doi.org/10.1016/bs.pbr.2015.01.005. (http://www.sciencedirect.com/science/article/pii/S0079612315000060)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65296
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:11 Mar 2016 22:34
Last Modified:20 Jul 2017 22:26

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