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Decellularized Extracellular Matrix Microparticles as a Vehicle for Cellular Delivery in a Model of Anastomosis Healing

Hoganson, David M. and Owens, Gwen E. and Meppelink, Amanda M. and Bassett, Erik K. and Bowley, Chris M. and Hinkel, Cameron J. and Finkelstein, Eric B. and Goldman, Scott M. and Vacanti, Joseph P. (2016) Decellularized Extracellular Matrix Microparticles as a Vehicle for Cellular Delivery in a Model of Anastomosis Healing. Journal of Biomedical Materials Research Part A, 104 (7). pp. 1728-1735. ISSN 1549-3296. doi:10.1002/jbm.a.35703.

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Extracellular matrix (ECM) materials from animal and human sources have become important materials for soft tissue repair. Microparticles of ECM materials have increased surface area and exposed binding sites compared to sheet materials. Decellularized porcine peritoneum was mechanically dissociated into 200 µm microparticles, seeded with fibroblasts and cultured in a low gravity rotating bioreactor. The cells avidly attached and maintained excellent viability on the microparticles. When the seeded microparticles were placed in a collagen gel, the cells quickly migrated off the microparticles and through the gel. Cells from seeded microparticles migrated to and across an in vitro anastomosis model, increasing the tensile strength of the model. Cell seeded microparticles of ECM material have potential for paracrine and cellular delivery therapies when delivered in a gel carrier.

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Additional Information:© 2016 Wiley Periodicals, Inc. A portion of these data were presented in abstract form at the annual meeting of the Society for Biomaterials April 10th-13th, 2013.
Subject Keywords:cell adhesion; 3-D cell culture; cell migration; ECM (extracellular matrix); microparticles
Issue or Number:7
Record Number:CaltechAUTHORS:20160315-091946653
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Official Citation:Hoganson DM, Owens GE, Meppelink AM, Bassett EK, Bowley CM, Hinkel CJ, Finkelstein EB, Goldman SM, Vacanti JP. 2016. Decellularized extracellular matrix microparticles as a vehicle for cellular delivery in a model of anastomosis healing. J Biomed Mater Res Part A 2016:104A:1728–1735
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65352
Deposited By: Tony Diaz
Deposited On:15 Mar 2016 16:49
Last Modified:10 Nov 2021 23:44

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