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Excess Lunatic Fringe Causes Cranial Neural Crest Over-Proliferation

Nellemann, Christine and De Bellard, Maria Elena and Barembaum, Meyer and Laufer, Ed and Bronner-Fraser, Marianne (2001) Excess Lunatic Fringe Causes Cranial Neural Crest Over-Proliferation. Developmental Biology, 235 (1). pp. 121-130. ISSN 0012-1606. https://resolver.caltech.edu/CaltechAUTHORS:20160317-081242469

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Abstract

Lunatic fringe is a vertebrate homologue of Drosophila fringe, which plays an important role in modulating Notch signaling. This study examines the distribution of chick lunatic fringe at sites of neural crest formation and explores its possible function by ectopic expression. Shortly after neural tube closure, lunatic fringe is expressed in most of the neural tube, with the exception of the dorsal midline containing presumptive neural crest. Thus, there is a fringe/non-fringe border at the site of neural crest production. Expression of excess lunatic fringe in the cranial neural tube and neural crest by retrovirally mediated gene transfer resulted in a significant increase (∼60%) in the percentage of cranial neural crest cells 1 day after infection. This effect was mediated by an increase in cell division as assayed by BrdU incorporation. Infected embryos had an up-regulation of Delta-1 in the dorsal neural tube and redistribution of Notch-1 to the lumen of the neural tube, confirming that excess fringe modulates Notch signaling. These findings point to a novel role for lunatic fringe in regulating cell division and/or production of neural crest cells by the neural tube.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1006/dbio.2001.0279DOIArticle
http://www.sciencedirect.com/science/article/pii/S0012160601902799PublisherArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 2001 Academic Press. Submitted for publication January 8, 2001. Revised March 23, 2001. Accepted March 28, 2001. Published online May 30, 2001. We thank Dr. Gerry Weinmaster for helpful comments on the manuscript and Ruel Velasco for help with sectioning. This work was supported by NS36585 and DE13223.
Funders:
Funding AgencyGrant Number
NIHNS36585
NIHDE13223
Issue or Number:1
Record Number:CaltechAUTHORS:20160317-081242469
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160317-081242469
Official Citation:Christine Nellemann, Maria Elena de Bellard, Meyer Barembaum, Ed Laufer, Marianne Bronner-Fraser, Excess Lunatic Fringe Causes Cranial Neural Crest Over-Proliferation, Developmental Biology, Volume 235, Issue 1, 1 July 2001, Pages 121-130, ISSN 0012-1606, http://dx.doi.org/10.1006/dbio.2001.0279. (http://www.sciencedirect.com/science/article/pii/S0012160601902799)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65410
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:17 Mar 2016 20:02
Last Modified:03 Oct 2019 09:47

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