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Magnesium-embedded live cell filter for CTC isolation

Liu, Yang and Park, Jungwook and Xu, Tong and Chang, Jay Han-Chieh and Kang, Dongyang and Zhang, Xiaoxiao and Goldkorn, Amir and Tai, Yu-Chong (2015) Magnesium-embedded live cell filter for CTC isolation. In: 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2015). IEEE , Piscataway, NJ, pp. 340-343. ISBN 978-1-4799-7955-4.

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This paper reports a novel Magnesium-embedded cell filter for Circulating Tumor Cell (CTC) capture, release and isolation. The new and novel feature is the use of thin-film Mg to release the captured CTCs based on the fact that any Cl^- containing culture medium can readily etch Mg away [1]. The releasing and the isolation of each individual CTC are demonstrated here. After filtration process, the filter is submerged in PBS to facilitate Mg etching. The top PA-C filter pieces break apart from the bottom after Mg completely dissolves, enabling captured CTC cells to detach from the filter. The released CTC can then be easily aspirated into a micropipette, and then for further, such as, DNA mutation analysis.

Item Type:Book Section
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URLURL TypeDescription DOIArticle
Liu, Yang0000-0002-8155-9134
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2015 IEEE. The authors gratefully acknowledge the help of all the members in California Institute of Technology (Caltech) Micromachining Lab, and University of Southern California (USC) Keck School of Medicine Norris Comprehensive Cancer Center, as well as experimental assistance of Mr. Trevor Roper.
Record Number:CaltechAUTHORS:20160317-142858089
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Official Citation:Y. Liu et al., "Magnesium-embedded live cell filter for CTC isolation," Micro Electro Mechanical Systems (MEMS), 2015 28th IEEE International Conference on, Estoril, 2015, pp. 340-343. doi: 10.1109/MEMSYS.2015.7050958
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65453
Deposited By: Tony Diaz
Deposited On:18 Mar 2016 16:48
Last Modified:09 Mar 2020 13:19

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