A Caltech Library Service

Wearable flexible micro electrode for adult zebrafish long term ecgmonitoring

Zhang, Xiaoxiao and Beebe, Tyler and Liu, Yang and Park, Jungwook and Hsiai, Tzung K. and Tai, Yu-Chong (2015) Wearable flexible micro electrode for adult zebrafish long term ecgmonitoring. In: 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2015). IEEE , Piscataway, NJ, pp. 690-693. ISBN 978-1-4799-7955-4.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


During the last decade, close resemblance between the zebrafish heart and human heart physiology has been discovered [1] andzebrafish (Danio rerio) has become an emerging animal model for studying side effects developmental drugs may impose on the heart [2][3]. More interestingly, contrary to human heart the zebrafish heart has a remarkable ability to “regenerate” after severe injury [4], making it also a popular model for studies of regenerative medicine. On the other hand, Electrocardiogram (ECG) is a widely used tool to monitor the physiological changes of the zebrafish heart. However, due to its in-water habitat, a long term ECG monitoring solution, although very much needed, was not present. All published adult zebrafish ECG recorded to this date have been done acutely with anesthetized fish. This work presents, for the first time a wearable flexible parylene (PA) micro-electrode that monitors the Adult Zebrafish ECG long term. We show here the design, fabrication and testing of the flexible electrode along with a micro-molded ultra-soft, density adjusted silicone jacket, allowing ECG recording to be carried under water, in the fish's natural habitat with no need for anesthesia.

Item Type:Book Section
Related URLs:
URLURL TypeDescription DOIArticle
Liu, Yang0000-0002-8155-9134
Hsiai, Tzung K.0000-0003-1734-0792
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2015 IEEE. This work is partially funded by the NIH, grant number R01 HL111437. The author would like to thank all Caltech MEMS group members for their fruitful discussions and suggestions.
Funding AgencyGrant Number
NIHR01 HL111437
Record Number:CaltechAUTHORS:20160317-144512824
Persistent URL:
Official Citation:X. Zhang, T. Beebe, Y. Liu, J. Park, T. Hsiai and Y. C. Tai, "Wearable flexible micro electrode for adult zebrafish long term ecgmonitoring," Micro Electro Mechanical Systems (MEMS), 2015 28th IEEE International Conference on, Estoril, 2015, pp. 690-693. doi: 10.1109/MEMSYS.2015.7051051
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65456
Deposited By: Tony Diaz
Deposited On:18 Mar 2016 16:50
Last Modified:25 Nov 2019 23:39

Repository Staff Only: item control page