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A Wireless EeG Recording System for Small Animal Models of Heart Regeneration

Cao, Hung and Zhao, Yu and Kouki, Ammar B. and Tai, Yu-Chong and Hsiai, Tzung K. (2015) A Wireless EeG Recording System for Small Animal Models of Heart Regeneration. In: 2015 IEEE MTT-S International Microwave Symposium. IEEE , Piscataway, NJ, pp. 1-3. ISBN 978-1-4799-8275-2. https://resolver.caltech.edu/CaltechAUTHORS:20160318-083235523

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Abstract

Heart failure afflicts the developed world, causing mortality more than any other diseases. This is due to the fact that humans' heart possesses a very limited capacity to regenerate. Heart attacks or myocardial infarction (MI) could result in an irreversible loss of cardiomyocytes and consequently heart failure. Besides, zebrafish and neonatal mice are well-known for their magical capacity to recover after ventricular amputation, thus becoming precious models for heart regeneration studies. In this work, we report the first wireless electrocardiography (ECG) recording system for small animal models of heart regeneration. The system consists of a microelectrode array (MEA) and electronic components for wireless powering, signal processing and data communication. The MEA is based on a biocompatible and flexible polymer so it could conform to non-planar anatomical surfaces. The power transfer is achieved using inductive coupling between two solenoids and the ECG signals are sent through an optical link. The wireless operation can free the animal, eliminating anesthesia during experiments and thus minimizing unwanted side effects. The first generation of the device was demonstrated successfully with neonatal mice, revealing awake ECG signals with all features, thereby paving the way to physiologically investigate heart regeneration in long-term without disrupting the animals' normal activities.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1109/MWSYM.2015.7167081 DOIArticle
ORCID:
AuthorORCID
Tai, Yu-Chong0000-0001-8529-106X
Hsiai, Tzung K.0000-0003-1734-0792
Additional Information:© 2015 IEEE. The studies were supported by the National Institutes of Health R01HL-083015 (T.K.H. ) and R01HL111437 (T.K.H.).
Funders:
Funding AgencyGrant Number
NIHR01HL083015
NIHR01HL111437
Subject Keywords:Wireless ECG, flexible MEA, zebrafish, neonatal mice, inductive coupling, heart regeneration
Record Number:CaltechAUTHORS:20160318-083235523
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160318-083235523
Official Citation:H. Cao, Y. Zhao, A. B. Kouki, Yu-chong Tai and T. K. Hsiai, "A wireless ECG recording system for small animal models of heart regeneration," Microwave Symposium (IMS), 2015 IEEE MTT-S International, Phoenix, AZ, 2015, pp. 1-3. doi: 10.1109/MWSYM.2015.7167081
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65471
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:18 Mar 2016 16:37
Last Modified:25 Nov 2019 23:44

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