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Partial N-terminal amino acid sequences of three nonstructural proteins of two flaviviruses

Rice, Charles M. and Aebersold, Ruedi and Teplow, David B. and Pata, Janice and Bell, John R. and Vorndam, A. Vance and Trent, Dennis W. and Brandriss, Michael W. and Schlesinger, Jacob J. and Strauss, James H. (1986) Partial N-terminal amino acid sequences of three nonstructural proteins of two flaviviruses. Virology, 151 (1). pp. 1-9. ISSN 0042-6822. doi:10.1016/0042-6822(86)90098-X.

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Partial N-terminal amino acid sequences for the three largest nonstructural proteins of two flaviviruses, yellow fever virus and St. Louis encephalitis virus, have been obtained. The determined sequences of these proteins exhibit significant amino acid sequence homology, and allow the positioning of these three nonstructural proteins in the polyprotein sequence deduced from the nucleotide sequence of yellow fever virus (C. M. Rice, E. M. Lenches, S. R. Eddy, S. J. Shin, R. L. Sheets, and J. H. Strauss, 1985, Science 229, 726-733.) The deduced start points support the hypothesis that the N terminus of nonstructural glycoprotein NSl results from cleavage by signalase, whereas the N termini of NS3 and NS5 result from cleavages following double basic residues that are flanked by amino acids with short side chains.

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Additional Information:© 1986 Academic Press, Inc. Received November 12, 1985; accepted January 22, 1986 We gratefully acknowledge the competent technical assistance of E. Lenches. We are grateful to E. Strauss for help with the manuscript and in producing the figures. The computer facility of L. Hood and the programs written by T. Hunkapiller were of great value in producing the figures. This work was supported by Grants AI 20612, AI 10793 from NIH and Grant DMB 83-16856 from NSF. R.A. was the recipient of a training fellowship from the Swiss National Foundation.
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NIHAI 20612
NIHAI 10793
NSFDMB 83-16856
Swiss National FoundationUNSPECIFIED
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Record Number:CaltechAUTHORS:20160321-150516329
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ID Code:65557
Deposited By: Donna Wrublewski
Deposited On:22 Mar 2016 19:38
Last Modified:10 Nov 2021 23:47

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