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The Receptor Tyrosine Kinase QEK5 mRNA Is Expressed in a Gradient within the Neural Retina and the Tectum

Kenny, Daryn and Bronner-Fraser, Marianne and Marcelle, Christophe (1995) The Receptor Tyrosine Kinase QEK5 mRNA Is Expressed in a Gradient within the Neural Retina and the Tectum. Developmental Biology, 172 (2). pp. 708-716. ISSN 0012-1606. doi:10.1006/dbio.1995.8083.

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In the retinotectal system, positional information has long been postulated to take the form of molecular gradients within both the retina and the tectum. Recent reports have implicated Mek4, a member of the Eph (also named class V) family of tyrosine kinase receptors (RTKs), and two ligands, RAGS and ELF-1, in this process. Here, we report the cloning and distribution pattern of QEK5, another member of the Eph family of RTKs, isolated from a quail cDNA library. During retinal differentiation, QEK5 transcripts accumulate in a ventral to dorsal gradient within the retinal neuroepithelium, where its expression becomes restricted to the ganglion and bipolar cell layers. Within the tectum, QEK5 transcripts are detectable in a posterior to anterior gradient in the ventricular layer and newly formed superficial layers. The pattern of QEK5 expression in the retina and tectum is distinct from that of Mek4, suggesting that complex patterns of Eph RTKs and their ligands may play a role in cell–cell interactions involved in retinotectal projections and differentiation of the central nervous system.

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Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 1995 Published by Elsevier Inc. Received 26 September 1995, Accepted 19 October 1995, Available online 7 May 2002. We thank Dr. S. Fraser for a critical reading of this manuscript. Christophe Marcelle is a fellow of the Human Frontier Science Program Organization. This work was supported by HD 15527 and a grant from the Muscular Dystrophy Association.
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Muscular Dystrophy AssociationUNSPECIFIED
Issue or Number:2
Record Number:CaltechAUTHORS:20160322-094126074
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Official Citation:Daryn Kenny, Marianne Bronner-Fraser, Christophe Marcelle, The Receptor Tyrosine Kinase QEK5 mRNA Is Expressed in a Gradient within the Neural Retina and the Tectum, Developmental Biology, Volume 172, Issue 2, December 1995, Pages 708-716, ISSN 0012-1606, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65583
Deposited By: Ruth Sustaita
Deposited On:22 Mar 2016 17:51
Last Modified:10 Nov 2021 23:47

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