Britten, Roy J. (1997) Mobile elements inserted in the distant past have taken on important functions. Gene, 205 (1-2). pp. 177-182. ISSN 0378-1119. doi:10.1016/S0378-1119(97)00399-5. https://resolver.caltech.edu/CaltechAUTHORS:20160323-091824746
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Abstract
Current evidence on the long-term evolutionary effect of insertion of sequence elements is reviewed. There are three criteria for inclusion of an example: (i) the element was inserted far in the past and thus the event is not a transient mutation; (ii) the element is a member of a large group of similar sequences; (iii) the element now serves a useful function. There are 21 examples from Drosophila, sea urchin, human and mouse genomes that meet these criteria. Taken together, these examples show that the insertion of sequence elements in the genome has been a significant source of regulatory variation in evolution.
| Item Type: | Article | |||||||||
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| Additional Information: | © 1997 Elsevier Science B.V. Accepted 16 June 1997. Available online 10 November 1998. This work was supported by NIH grants. | |||||||||
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| Subject Keywords: | Alu repeats; Retrotransposons; Transcriptional regulation; MIR repeat | |||||||||
| Issue or Number: | 1-2 | |||||||||
| DOI: | 10.1016/S0378-1119(97)00399-5 | |||||||||
| Record Number: | CaltechAUTHORS:20160323-091824746 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160323-091824746 | |||||||||
| Official Citation: | Roy J. Britten, Mobile elements inserted in the distant past have taken on important functions, Gene, Volume 205, Issues 1–2, 31 December 1997, Pages 177-182, ISSN 0378-1119, http://dx.doi.org/10.1016/S0378-1119(97)00399-5. (http://www.sciencedirect.com/science/article/pii/S0378111997003995) | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 65610 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Ruth Sustaita | |||||||||
| Deposited On: | 23 Mar 2016 16:59 | |||||||||
| Last Modified: | 10 Nov 2021 23:47 |
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