Bronner-Fraser, Marianne (1995) Hepatocyte growth factor/scatter factor (HGF/SF) in early development: evidence for a role in neural induction. Trends in Genetics, 11 (11). pp. 423-425. ISSN 0168-9525. doi:10.1016/S0168-9525(00)89136-2. https://resolver.caltech.edu/CaltechAUTHORS:20160323-134516599
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Abstract
Since the pioneering work of Spemann and Mangold, who found that transplantation of the dorsal lip of the frog blastopore produces a secondary neural axis, embryologists have been intrigued by the process of neural induction. However, the molecular nature of the inducer(s) has remained obscure, largely due to the complication that neural induction often occurs as a secondary consequence of mesodermal induction. In the past few years, candidate molecules have been identified that are able to induce neural tissue in the absence of mesodenn in the frog. These include noggin and follistatin (reviewed in Ref. 1), which are thought to function by inhibiting activin. In the chick, recent experiments have implicated hepatocyte growth factor/scatter factor (HGF/SF) as a neural inducer based on it5 expression in the primitive streak and Hensen's node of the early chick embryo, and its ability to induce neural tissue in naive epiblast. This review describes the evidence supporting the possible function of HGF/SF as an early embryonic inducer.
Item Type: | Article | |||||||||
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Additional Information: | © 1995 Published by Elsevier Ltd. Available online 14 August 2000. | |||||||||
Issue or Number: | 11 | |||||||||
DOI: | 10.1016/S0168-9525(00)89136-2 | |||||||||
Record Number: | CaltechAUTHORS:20160323-134516599 | |||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160323-134516599 | |||||||||
Official Citation: | Marianne Bronner-Fraser, Hepatocyte growth factor/scatter factor (HGF/SF) in early development: evidence for a role in neural induction, Trends in Genetics, Volume 11, Issue 11, November 1995, Pages 423-425, ISSN 0168-9525, http://dx.doi.org/10.1016/S0168-9525(00)89136-2. (http://www.sciencedirect.com/science/article/pii/S0168952500891362) | |||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
ID Code: | 65628 | |||||||||
Collection: | CaltechAUTHORS | |||||||||
Deposited By: | Ruth Sustaita | |||||||||
Deposited On: | 24 Mar 2016 17:43 | |||||||||
Last Modified: | 10 Nov 2021 23:48 |
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