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Hepatocyte growth factor/scatter factor (HGF/SF) in early development: evidence for a role in neural induction

Bronner-Fraser, Marianne (1995) Hepatocyte growth factor/scatter factor (HGF/SF) in early development: evidence for a role in neural induction. Trends in Genetics, 11 (11). pp. 423-425. ISSN 0168-9525. doi:10.1016/S0168-9525(00)89136-2. https://resolver.caltech.edu/CaltechAUTHORS:20160323-134516599

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Abstract

Since the pioneering work of Spemann and Mangold, who found that transplantation of the dorsal lip of the frog blastopore produces a secondary neural axis, embryologists have been intrigued by the process of neural induction. However, the molecular nature of the inducer(s) has remained obscure, largely due to the complication that neural induction often occurs as a secondary consequence of mesodermal induction. In the past few years, candidate molecules have been identified that are able to induce neural tissue in the absence of mesodenn in the frog. These include noggin and follistatin (reviewed in Ref. 1), which are thought to function by inhibiting activin. In the chick, recent experiments have implicated hepatocyte growth factor/scatter factor (HGF/SF) as a neural inducer based on it5 expression in the primitive streak and Hensen's node of the early chick embryo, and its ability to induce neural tissue in naive epiblast. This review describes the evidence supporting the possible function of HGF/SF as an early embryonic inducer.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0168-9525(00)89136-2DOIArticle
http://www.sciencedirect.com/science/article/pii/S0168952500891362PublisherArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 1995 Published by Elsevier Ltd. Available online 14 August 2000.
Issue or Number:11
DOI:10.1016/S0168-9525(00)89136-2
Record Number:CaltechAUTHORS:20160323-134516599
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160323-134516599
Official Citation:Marianne Bronner-Fraser, Hepatocyte growth factor/scatter factor (HGF/SF) in early development: evidence for a role in neural induction, Trends in Genetics, Volume 11, Issue 11, November 1995, Pages 423-425, ISSN 0168-9525, http://dx.doi.org/10.1016/S0168-9525(00)89136-2. (http://www.sciencedirect.com/science/article/pii/S0168952500891362)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65628
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:24 Mar 2016 17:43
Last Modified:10 Nov 2021 23:48

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