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The origins of the neural crest. Part I: embryonic induction

Baker, Clare V. H. and Bronner-Fraser, Marianne (1997) The origins of the neural crest. Part I: embryonic induction. Mechanisms of Development, 69 (1-2). pp. 3-11. ISSN 0925-4773. https://resolver.caltech.edu/CaltechAUTHORS:20160323-142239679

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Abstract

Neural crest cells form at the border between the neural plate and the epidermis. The tissue interactions that underlie neural crest cell induction have been investigated primarily by heterotopic grafting experiments in vivo and by conjugating different tissues in vitro. Three models have been proposed to explain the induction of neural crest cells at the neural plate border, i.e. (1) the influence of signals from the mesoderm, (2) changes in ectodermal competence and (3) local interactions between neural and non-neural ectoderm. The weight of the evidence supports the last model, although there are data that suggest a role for signals from the mesoderm. FGFs seem to be necessary but not sufficient for neural crest cell induction. BMP-4 is sufficient to induce neural crest cells from chick neural explants in vitro and intermediate levels of BMP-4-signalling induce neural crest cell markers in Xenopus animal cap assays. These data suggest a gradient model in which neural crest cells are induced by a particular range of BMP-4 activity, although a single-signal model may be too simplistic. Neural crest cell induction may be an ongoing process, in which an initial induction at the neural plate border is followed by further induction within the dorsal neural tube.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0925-4773(97)00132-9DOIArticle
http://www.sciencedirect.com/science/article/pii/S0925477397001329PublisherArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 1997 Elsevier Science Ireland Ltd. Received 15 May 1997; revised version received 11 August 1997; accepted 11 August 1997. Available online 19 February 1998. The authors are indebted to Drs Carole LaBonne and Mary Dickinson for insightful discussion and for critical reading of the manuscript.
Subject Keywords:Neural crest; Induction; Xenopus; Chick; BMP; FGF
Issue or Number:1-2
Record Number:CaltechAUTHORS:20160323-142239679
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160323-142239679
Official Citation:Clare V.H Baker, Marianne Bronner-Fraser, The origins of the neural crest. Part I: embryonic induction, Mechanisms of Development, Volume 69, Issues 1–2, December 1997, Pages 3-11, ISSN 0925-4773, http://dx.doi.org/10.1016/S0925-4773(97)00132-9. (http://www.sciencedirect.com/science/article/pii/S0925477397001329)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65632
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:24 Mar 2016 17:27
Last Modified:03 Oct 2019 09:49

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