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Schwann Cell CD9 Expression Is Regulated by Axons

Banerjee, Shilpi A. and Patterson, Paul H. (1995) Schwann Cell CD9 Expression Is Regulated by Axons. Molecular and Cellular Neuroscience, 6 (5). pp. 462-473. ISSN 1044-7431. doi:10.1006/mcne.1995.1034.

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The cell-surface glycoprotein, CD9, has been implicated in hematopoietic and Schwann cell signaling in vitro. In vivo, Schwann cell CD9 expression follows a developmental time course that parallels that of myelin genes. Here we report that Schwann cell CD9 mRNA expression is regulated by axonal contact in culture and in vivo. Following adult rat sciatic nerve injury, CD9 mRNA expression in distal nerve sections is correlated with the presence of axons; CD9 is down-regulated when axons are degenerating and is reexpressed when axons are regenerating, but not if they are prevented from doing so by transection. CD9 regulation in cultured Schwann cells is also dependent on the presence of neurons such that dissociated Schwann cells down-regulate CD9 mRNA expression in culture, but in the presence of sensory neurons they continue to express CD9. Therefore, regulation of Schwann cell CD9 expression parallels that of myelin genes protein O and myelin basic protein in culture and in vivo. A signaling role for CD9 in nerve development and regeneration is proposed.

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Additional Information:© 1995 Academic Press. Received July 28, 1995. Revised August 28, 1995. Accepted August 28, 1995. Available online 2 May 2002. This work was supported by an NINDS grant to P,H.P. and a Muscular Dystrophy Association Research Fellowship to S.A.B. We thank Drs. Zaven Kaprielian, Lisa Banner, and Andy Groves for advice; Doreen McDowell for media preparation; and Ors. Lisa Banner, Michael Hadjiargyrou, and Karen Allendoerfer for critically reading the manuscript.
Funding AgencyGrant Number
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
Muscular Dystrophy AssociationUNSPECIFIED
Issue or Number:5
Record Number:CaltechAUTHORS:20160324-065119837
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Official Citation:Shilpi A. Banerjee, Paul H. Patterson, Schwann Cell CD9 Expression Is Regulated by Axons, Molecular and Cellular Neuroscience, Volume 6, Issue 5, October 1995, Pages 462-473, ISSN 1044-7431, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65637
Deposited By: Ruth Sustaita
Deposited On:24 Mar 2016 16:19
Last Modified:10 Nov 2021 23:48

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