CaltechAUTHORS
  A Caltech Library Service

Amino-terminal amino acid sequences of structural proteins of three flaviviruses

Bell, John R. and Kinney, Richard M. and Trent, Dennis W. and Lenches, Edith M. and Dalgarno, Lynn and Strauss, James H. (1985) Amino-terminal amino acid sequences of structural proteins of three flaviviruses. Virology, 143 (1). pp. 224-229. ISSN 0042-6822. http://resolver.caltech.edu/CaltechAUTHORS:20160328-153821185

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20160328-153821185

Abstract

N-terminal amino acid sequences of structural proteins of three flaviviruses, yellow fever, St. Louis encephalitis, and dengue-2 viruses, have been obtained. The glycoproteins of these three viruses are 52-60% conserved in the region sequenced, depending upon which pair of viruses are compared, and 40% of the amino acids are invariant in all three viruses. Thus, flaviviruses are closely related and have in all probability descended from a common ancestor. Furthermore, residues important in the secondary structure of proteins are conserved, suggesting that the overall conformation of the glycoproteins is the same in all three viruses while considerable variation in the primary sequence can be accommodated. The N-terminal regions of the nucleocapsid proteins of yellow fever and St. Louis encephalitis viruses show markedly less homology (25%) and this region is highly basic with one-quarter (yellow fever) or one-third (St. Louis encephalitis) of the residues being lysine or arginine. N-terminal sequences for the M protein of yellow fever and for NV2(GP19) of St. Louis encephalitis viruses are also reported.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/0042-6822(85)90110-2DOIArticle
http://www.sciencedirect.com/science/article/pii/0042682285901102PublisherArticle
Additional Information:© 1985 Academic Press, Inc. Received November 1, 1984; accepted December 17, 1984. This work has been supported in part by Grants GM 06965, AI 10793, and AI 20612 from NIH and by Grant PCM 83-16856 from NSF.
Funders:
Funding AgencyGrant Number
NIHGM 06965
NIHAI 10793
NIHAI 20612
NSFPCM 83-16856
Record Number:CaltechAUTHORS:20160328-153821185
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160328-153821185
Official Citation:John R. Bell, Richard M. Kinney, Dennis W. Trent, Edith M. Lenches, Lynn Dalgarno, James H. Strauss, Amino-terminal amino acid sequences of structural proteins of three flaviviruses, Virology, Volume 143, Issue 1, May 1985, Pages 224-229, ISSN 0042-6822, http://dx.doi.org/10.1016/0042-6822(85)90110-2. (http://www.sciencedirect.com/science/article/pii/0042682285901102)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65717
Collection:CaltechAUTHORS
Deposited By: Donna Wrublewski
Deposited On:28 Mar 2016 23:12
Last Modified:28 Mar 2016 23:12

Repository Staff Only: item control page