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Mouse Lemur Microscopic MRI Brain Atlas

Ghosh, Pratik and O'Dell, Mark and Narasimhan, P. T. and Fraser, Scott E. and Jacobs, Russell E. (1994) Mouse Lemur Microscopic MRI Brain Atlas. NeuroImage, 1 (4). pp. 345-349. ISSN 1053-8119.

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We present a three-dimensional (3D) digital atlas of a mouse lemur head at 60-μm cubic voxel isotropic resolution. It was constructed from a 3D proton magnetic resonance image (MRI) acquired at 500 MHz. It shows views of 3D volume-rendering and movies of contiguous 2D plane cuts in three orthogonal directions. This MR data set was acquired using a spin-echo pulse sequence under conditions of strong T_2 and significant diffusion weighting. Experimental parameters were optimized to provide strong intrinsic contrast between gray and white matter. Familiar anatomical structures are clearly identifiable. Fine fiber tracts, laminations of cortices, details of the inner ears, and layering in the lateral geniculate nuclei are all visible. Anatomical identifications of structures in representative slices selected from the atlas are presented. We also describe some difficulties and trade-offs encountered in microscopic resolution MRI. We note that this type of atlas does not suffer from the spatial distortions and slice registration problems introduced by standard histological techniques. Future in vivo longitudinal studies will provide atlases describing in detail the development of the primate brain.

Item Type:Article
Related URLs:
URLURL TypeDescription
Fraser, Scott E.0000-0002-5377-0223
Jacobs, Russell E.0000-0002-1382-8486
Additional Information:© 1994 Academic Press. Received September 1, 1994. We thank David Haring of the Duke Primate Center for his generous gift of the specimen used in this work and John Allman for help in obtaining it. John Allman and Michael Figdor helped with identification of anatomical structures in the atlas. David Laidlaw was of invaluable assistance in image processing and manipulations. This Human Brain Project research is funded jointly by the National Institute of Drug Abuse, the National Institute of Mental Health, and the National Science Foundation.
Funding AgencyGrant Number
National Institute on Drug AbuseUNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
Issue or Number:4
Record Number:CaltechAUTHORS:20160330-140244477
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Official Citation:Pratik Ghosh, Mark O'Dell, P.T. Narasimhan, Scott E. Fraser, Russell E. Jacobs, Mouse Lemur Microscopic MRI Brain Atlas, NeuroImage, Volume 1, Issue 4, November 1994, Pages 345-349, ISSN 1053-8119, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65770
Deposited By: Ruth Sustaita
Deposited On:30 Mar 2016 23:18
Last Modified:03 Oct 2019 09:50

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