Tirrell, David and Fang, Katherine and Lieblich, Seth (2016) Non-canonical amino acids as tools for protein medicinal chemistry. In: 251st American Chemical Society National Meeting & Exposition, March 13-17, 2016, San Diego, CA. https://resolver.caltech.edu/CaltechAUTHORS:20160331-090004894
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Abstract
The engineering of therapeutic proteins has been advanced enormously by methods for site-directed mutagenesis. This lecture will describe an alternative, complementary approach, in which non- canonical amino acids are used to engineer protein-protein interactions, protein solvation and chain trajectory, with the objective of controlling the stability and pharmacokinetics of protein therapeutics.
| Item Type: | Conference or Workshop Item (Paper) | ||||||
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| Additional Information: | © 2016 American Chemical Society. | ||||||
| Record Number: | CaltechAUTHORS:20160331-090004894 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160331-090004894 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 65790 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 31 Mar 2016 20:19 | ||||||
| Last Modified: | 03 Oct 2019 09:50 |
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