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Non-canonical amino acids as tools for protein medicinal chemistry

Tirrell, David and Fang, Katherine and Lieblich, Seth (2016) Non-canonical amino acids as tools for protein medicinal chemistry. In: 251st American Chemical Society National Meeting & Exposition, March 13-17, 2016, San Diego, CA.

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The engineering of therapeutic proteins has been advanced enormously by methods for site-directed mutagenesis. This lecture will describe an alternative, complementary approach, in which non- canonical amino acids are used to engineer protein-protein interactions, protein solvation and chain trajectory, with the objective of controlling the stability and pharmacokinetics of protein therapeutics.

Item Type:Conference or Workshop Item (Paper)
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Tirrell, David0000-0003-3175-4596
Additional Information:© 2016 American Chemical Society.
Record Number:CaltechAUTHORS:20160331-090004894
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65790
Deposited By: Tony Diaz
Deposited On:31 Mar 2016 20:19
Last Modified:03 Oct 2019 09:50

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