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Characterization of the Boundaries between Adjacent Rapidly and Slowly Evolving Genomic Regions in Drosophila

Martin, Christopher H. and Meyerowitz, Elliot M. (1986) Characterization of the Boundaries between Adjacent Rapidly and Slowly Evolving Genomic Regions in Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 83 (22). pp. 8654-8658. ISSN 0027-8424. PMCID PMC386989.

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The site of a dramatic change in the rate of DNA sequence evolution exists near the 68C glue gene clusters of several Drosophila species. We have previously determined the approximate location of this transition site by comparison of restriction maps of the regions flanking the 68C-like glue gene cluster of five members of the melanogaster species subgroup. In the present work we report the sequence of the transition region in three of these Drosophila species: D. melanogaster, D. yakuba, and D. erecta. Using a best-fit alignment of these sequences, we find that the site of transition from slowly to rapidly evolving sequences occurs abruptly within a region <50 nucleotides in length. Although frequency of nucleotide substitutions changes as much as 10-fold across this boundary, frequency of small insertion/deletion events stays nearly constant.

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Meyerowitz, Elliot M.0000-0003-4798-5153
Additional Information:© 1986 National Academy of Sciences. Communicated by Roy J. Britten, August 4, 1986. We thank Joan Kobori, Erich Strauss, and Frank Calzone for discussions of sequencing techniques. We also thank the members of the Meyerowitz lab for their helpful suggestions on the manuscript. This work was supported by Grant GM20927 from the National Institutes of Health. C.H.M. was supported by a National Science Foundation Predoctoral Fellowship and by a Graduate Fellowship from the General Electric Foundation. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Funding AgencyGrant Number
NSF Predoctoral FellowshipUNSPECIFIED
General Electric FoundationUNSPECIFIED
Subject Keywords:glue protein genes, genome structure, evolution
Issue or Number:22
PubMed Central ID:PMC386989
Record Number:CaltechAUTHORS:MARpnas86
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Official Citation:C H Martin and E M Meyerowitz Characterization of the boundaries between adjacent rapidly and slowly evolving genomic regions in Drosophila PNAS 1986 83 (22) 8654-8658
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:658
Deposited By: Archive Administrator
Deposited On:12 Sep 2005
Last Modified:09 Mar 2020 23:23

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