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Topographical localization of iron in brains of the aged fat-tailed dwarf lemur (Cheirogaleus medius) and gray lesser mouse lemur (Microcebus murinus)

Gilissen, Emmanuel P. and Ghosh, Pratik and Jacobs, Russell E. and Allman, John M. (1998) Topographical localization of iron in brains of the aged fat-tailed dwarf lemur (Cheirogaleus medius) and gray lesser mouse lemur (Microcebus murinus). American Journal of Primatology, 45 (3). pp. 291-299. ISSN 0275-2565. https://resolver.caltech.edu/CaltechAUTHORS:20160331-132839745

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Abstract

Iron deposits in the human brain are characteristic of normal aging but have also been implicated in various neurodegenerative diseases. Among nonhuman primates, strepsirhines are of particular interest because hemosiderosis has been consistently observed in captive aged animals. In particular, the cheirogaleids, because of their small size, rapid maturity, fecundity, and relatively short life expectancy, are a useful model system for the study of normal and pathological cerebral aging. This study was therefore undertaken to explore iron localization in the brain of aged cheirogaleids (mouse and dwarf lemurs) with histochemistry and magnetic resonance microscopy. Results obtained with both techniques were comparable. There was no difference between old animals in the two species. The young animals (3 years old) showed no iron deposits. In the old animals (8–15 years old), iron pigments were mainly localized in the globus pallidus, the substantia nigra, the neocortical and cerebellar white matter, and anterior forebrain structures, including the nucleus basalis of Meynert. This distribution agrees with previous findings in monkeys and humans. In addition, we observed iron in the thalamus of these aged nonhuman primates. Microscopic NMR images clearly reveal many features seen with the histochemical procedure, and magnetic resonance microscopy is a powerful method for visualizing age-related changes in brain iron.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/(SICI)1098-2345(1998)45:3<291::AID-AJP5>3.0.CO;2-RDOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291098-2345%281998%2945:3%3C291::AID-AJP5%3E3.0.CO;2-R/abstractPublisherArticle
ORCID:
AuthorORCID
Jacobs, Russell E.0000-0002-1382-8486
Additional Information:© 1998 Wiley-Liss, Inc. Received for publication 23 June 1997; revision accepted 27 January 1998. We thank Kenneth Glander, Duke Primate Center, for providing the mouse lemur brains, Ludmilla Staneva-Dobrovski, University of Duesseldorf, David Haring, Duke University Primate Center, and Janet Baer, California Institute of Technology, for helpful assistance. Funding was provided by the von Humboldt and the Del Webb Foundations to E.G. Additional funding was provided by the Human Brain Project with contributions from the National Institute on Drug Abuse, the National Institute of Mental Health, and the National Science Foundation.
Funders:
Funding AgencyGrant Number
Alexander von Humboldt FoundationUNSPECIFIED
Del Webb FoundationUNSPECIFIED
Human Brain ProjectUNSPECIFIED
National Institute on Drug AbuseUNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
NSFUNSPECIFIED
Subject Keywords:cheirogaleids; iron; histochemistry; MR microscopy; neuro-degenerative diseases
Issue or Number:3
Record Number:CaltechAUTHORS:20160331-132839745
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160331-132839745
Official Citation:Gilissen, E. P., Ghosh, P., Jacobs, R. E. and Allman, J. M. (1998), Topographical localization of iron in brains of the aged fat-tailed dwarf lemur (Cheirogaleus medius) and gray lesser mouse lemur (Microcebus murinus). Am. J. Primatol., 45: 291–299. doi: 10.1002/(SICI)1098-2345(1998)45:3<291::AID-AJP5>3.0.CO;2-R
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65811
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:31 Mar 2016 22:41
Last Modified:03 Oct 2019 09:50

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