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Building a ladder to Hershey Heaven

Zinn, Kai (2016) Building a ladder to Hershey Heaven. eLife, 5 . Art. No. e15591. ISSN 2050-084X. PMCID PMC4821801. doi:10.7554/eLife.15591.

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When Alfred Hershey, one of the founders of molecular biology, was asked to describe his idea of scientific happiness, he said that it would be “to have one experiment that works, and keep doing it all the time”. By this he meant that it would be ideal to be able to conduct every experiment using the same tools and methods, and yet always generate new and interesting data (see Creager, 2001). However, molecular geneticists have not yet reached this “Hershey Heaven”. Today, when researchers want to discover more about a protein in an animal – for example, which tissues and cell types express the protein – they usually have to rely on antibodies that bind to the protein of interest. Unfortunately, good antibodies do not exist for most proteins, and it is time-consuming and expensive to generate and characterize new antibodies.

Item Type:Article
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URLURL TypeDescription CentralArticle
Zinn, Kai0000-0002-6706-5605
Additional Information:© 2016 Zinn. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. Published 29 March 2016. The author declares that no competing interests exist.
PubMed Central ID:PMC4821801
Record Number:CaltechAUTHORS:20160404-095334260
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Official Citation:Protein tagging: Building a ladder to Hershey Heaven Kai Zinn eLife 2016;5:e15591
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65889
Deposited By: Tony Diaz
Deposited On:04 Apr 2016 17:08
Last Modified:10 Nov 2021 23:50

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