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The vertebrate Hox gene regulatory network for hindbrain segmentation: Evolution and diversification

Parker, Hugo J. and Bronner, Marianne E. and Krumlauf, Robb (2016) The vertebrate Hox gene regulatory network for hindbrain segmentation: Evolution and diversification. Bioessays, 38 (6). pp. 526-538. ISSN 0265-9247. https://resolver.caltech.edu/CaltechAUTHORS:20160404-144238233

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Abstract

Hindbrain development is orchestrated by a vertebrate gene regulatory network that generates segmental patterning along the anterior–posterior axis via Hox genes. Here, we review analyses of vertebrate and invertebrate chordate models that inform upon the evolutionary origin and diversification of this network. Evidence from the sea lamprey reveals that the hindbrain regulatory network generates rhombomeric compartments with segmental Hox expression and an underlying Hox code. We infer that this basal feature was present in ancestral vertebrates and, as an evolutionarily constrained developmental state, is fundamentally important for patterning of the vertebrate hindbrain across diverse lineages. Despite the common ground plan, vertebrates exhibit neuroanatomical diversity in lineage-specific patterns, with different vertebrates revealing variations of Hox expression in the hindbrain that could underlie this diversification. Invertebrate chordates lack hindbrain segmentation but exhibit some conserved aspects of this network, with retinoic acid signaling playing a role in establishing nested domains of Hox expression.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/bies.201600010DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/bies.201600010/abstractPublisherArticle
ORCID:
AuthorORCID
Parker, Hugo J.0000-0001-7646-2007
Bronner, Marianne E.0000-0003-4274-1862
Krumlauf, Robb0000-0001-9102-7927
Additional Information:© 2016 Wiley Periodicals, Inc. Article first published online: 29 MAR 2016. We wish to thank members of the Krumlauf and Bronner labs for discussions, Mark Miller for illustrations, and the Stowers Institute for supporting HP and RK. The authors have declared no conflicts of interest.
Funders:
Funding AgencyGrant Number
Stowers Institute for Medical ResearchUNSPECIFIED
Subject Keywords:chordates; gene regulatory networks; hindbrain; Hox genes; rhombomeres; segmentation; vertebrate evolution
Issue or Number:6
Record Number:CaltechAUTHORS:20160404-144238233
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160404-144238233
Official Citation:Parker, H. J., Bronner, M. E. and Krumlauf, R. (2016), The vertebrate Hox gene regulatory network for hindbrain segmentation: Evolution and diversification. BioEssays, 38: 526–538. doi:10.1002/bies.201600010
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65903
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 Apr 2016 23:13
Last Modified:09 Mar 2020 13:19

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