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The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures

Smith, Elliot H. and Liou, Jyun-you and Davis, Tyler S. and Merricks, Edward M. and Kellis, Spencer S. and Weiss, Shennan A. and Greger, Bradley and House, Paul A. and McKhann, Guy M., II and Goodman, Robert R. and Emerson, Ronald G. and Bateman, Lisa M. and Trevelyan, Andrew J. and Schevon, Catherine A. (2016) The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures. Nature Communications, 7 . Art. No. 11098. ISSN 2041-1723. PMCID PMC4820627. https://resolver.caltech.edu/CaltechAUTHORS:20160404-145518758

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Abstract

The extensive distribution and simultaneous termination of seizures across cortical areas has led to the hypothesis that seizures are caused by large-scale coordinated networks spanning these areas. This view, however, is difficult to reconcile with most proposed mechanisms of seizure spread and termination, which operate on a cellular scale. We hypothesize that seizures evolve into self-organized structures wherein a small seizing territory projects high-intensity electrical signals over a broad cortical area. Here we investigate human seizures on both small and large electrophysiological scales. We show that the migrating edge of the seizing territory is the source of travelling waves of synaptic activity into adjacent cortical areas. As the seizure progresses, slow dynamics in induced activity from these waves indicate a weakening and eventual failure of their source. These observations support a parsimonious theory for how large-scale evolution and termination of seizures are driven from a small, migrating cortical area.


Item Type:Article
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http://dx.doi.org/10.1038/ncomms11098DOIArticle
http://www.nature.com/ncomms/2016/160329/ncomms11098/full/ncomms11098.htmlPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820627/PubMed CentralArticle
http://rdcu.be/hwbrPublisherFree ReadCube accesss
Additional Information:© 2016 Macmillan Publishers Limited. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Received 16 September 2015; Accepted 19 February 2016; Published 29 March 2016. We thank Lawrence F. Abbott and Charles E. Schroeder for helpful advice on the development of this manuscript. This work funded by NIH/NINDS R01 NS084142 (C.A.S.). These authors contributed equally to this work. Andrew J. Trevelyan & Catherine A. Schevon Author contributions: E.H.S., A.T. and C.A.S. wrote the manuscript. E.H.S. analysed the seizure data. J.-y.L. did the computational modelling. E.H.S., C.A.S., R.G.E., T.S.D. and B.G. collected the data. C.A.S., E.M.M., B.G., L.M.B. and A.J.T. provided developmental ideas. P.A.H., R.R.G. and G.M.M. implanted the MEAs. All authors contributed in editing the manuscript. The authors declare no competing financial interests.
Funders:
Funding AgencyGrant Number
NIHR01 NS084142
PubMed Central ID:PMC4820627
Record Number:CaltechAUTHORS:20160404-145518758
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160404-145518758
Official Citation:Smith, E. H. et al. The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures. Nat. Commun. 7:11098 doi: 10.1038/ncomms11098 (2016).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65906
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 Apr 2016 22:47
Last Modified:03 Oct 2019 09:51

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