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Molecular evolution of the MyoD family of transcription factors

Atchley, William R. and Fitch, Walter M. and Bronner-Fraser, Marianne (1994) Molecular evolution of the MyoD family of transcription factors. Proceedings of the National Academy of Sciences of the United States of America, 91 (24). pp. 11522-11526. ISSN 0027-8424. PMCID PMC45263.

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Myogenesis in skeletal muscle is a cascade of developmental events whose initiation involves the MyoD family of transcription factors. Evolutionary analyses of amino acid sequences of this family of transcriptional activators suggest that the vertebrate genes MyoD1, myf-5, Myog (myogenin), and myf-6 were derived by gene duplications from a single ancestral gene. A common genetic origin predicts some functional redundancy between MyoD1 and myf-5 and between Myog and myf-6. Experimental studies have suggested that these pairs of genes can substitute for each other during myogenesis. Separate analyses of the conserved basic helix-loop-helix and nonconserved flanking elements yield similar branching sequences but show evolutionary change in the basic helix-loop-helix region has occurred at a much slower rate.

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URLURL TypeDescription CentralArticle
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 1994 National Academy of Sciences. Contributed by Walter M. Fitch, August 17, 1994. We thank Drs. Charles Ordahl, Brian Williams, Susan Bryant, Eric Olson, and Michael Miyamoto for helpful comments on the manuscript and Helene Van for technical assistance. One of us (W.R.A.) is supported by the Alfred P. Sloan Foundation and by grants from the National Institutes of Health (GM-45344) and the National Science Foundation (BSR-910718). W.M.F. is supported by a grant from the National Science Foundation (DEB9096152). M.B.-F. was supported by Muscular Dystrophy Association and by grants from the National Institutes of Health (HD-15527, HD-25138, and DE-10066).
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Alfred P. Sloan FoundationUNSPECIFIED
Muscular Dystrophy AssociationUNSPECIFIED
Issue or Number:24
PubMed Central ID:PMC45263
Record Number:CaltechAUTHORS:20160405-094246992
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Official Citation:Molecular evolution of the MyoD family of transcription factors W R Atchley, W M Fitch, and M Bronner-Fraser PNAS 1994 91 (24) 11522-11526
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65920
Deposited By: Ruth Sustaita
Deposited On:05 Apr 2016 16:58
Last Modified:03 Oct 2019 09:51

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