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Leukemia Inhibitory Factor Is an Anti-Inflammatory and Analgesic Cytokine

Banner, Lisa R. and Patterson, Paul H. and Allchorne, Andrew and Poole, Steve and Woolf, Clifford J. (1998) Leukemia Inhibitory Factor Is an Anti-Inflammatory and Analgesic Cytokine. Journal of Neuroscience, 18 (14). pp. 5456-5462. ISSN 0270-6474. PMCID PMC6793494. doi:10.1523/jneurosci.18-14-05456.1998.

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The mRNA for leukemia inhibitory factor (LIF), a neuroimmune signaling molecule, is elevated during skin inflammation produced by intraplantar injection of complete Freund’s adjuvant (CFA). Moreover, although LIF knock-out mice display normal sensitivity to cutaneous mechanical and thermal stimulation compared with wild-type mice, the degree of CFA-induced inflammation in mice lacking LIF is enhanced in spatial extent, amplitude, cellular infiltrate, and interleukin (IL)-1β and nerve growth factor (NGF) expression. Conversely, local injection of low doses of recombinant LIF diminishes mechanical and thermal hypersensitivity as well as the IL-1β and NGF expression induced by CFA. These data show that upregulation of LIF during peripheral inflammation serves a key, early anti-inflammatory role and that exogenous LIF can reduce inflammatory hyperalgesia.

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Additional Information:© 1998 Society for Neuroscience. Beginning six months after publication the Work will be made freely available to the public on SfN’s website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license ( Received Nov. 20, 1997; revised April 10, 1998; accepted April 28, 1998. This work was supported by the Medical Research Council (C.J.W.), the Wellcome Trust (C.J.W.), the Human Frontiers Science Program (C.J.W.), the National Institutes of Health National Research Service Award (L.R.B.), and the National Institute of Neurological Diseases and Stroke (P.H.P.).
Funding AgencyGrant Number
Medical Research Council (UK)UNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
NIH Predoctoral FellowshipUNSPECIFIED
Subject Keywords:pain; inflammation; edema; hyperalgesia; primary sensory neuron; analgesia
Issue or Number:14
PubMed Central ID:PMC6793494
Record Number:CaltechAUTHORS:20160405-104522682
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Official Citation:Leukemia Inhibitory Factor Is an Anti-Inflammatory and Analgesic Cytokine Lisa R. Banner, Paul H. Patterson, Andrew Allchorne, Steve Poole, and Clifford J. Woolf The Journal of Neuroscience, 15 July 1998, 18(14):5456-5462
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65927
Deposited By: Ruth Sustaita
Deposited On:06 Apr 2016 18:51
Last Modified:10 Nov 2021 23:51

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