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Expression of Cell Adhesion Molecules During Initiation and Cessation of Neural Crest Cell Migration

Akitaya, Tatsuo and Bronner-Fraser, Marianne (1992) Expression of Cell Adhesion Molecules During Initiation and Cessation of Neural Crest Cell Migration. Developmental Dynamics, 194 (1). pp. 12-20. ISSN 1058-8388. https://resolver.caltech.edu/CaltechAUTHORS:20160405-112342750

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Abstract

Because of their distribution and known ability to promote neuronal adhesion, it has been proposed that N-CAM and N-cadherin are involved in the formation of the nervous system. Here, we examine the expression of these molecules during the initiation and cessation of trunk neural crest cell migration during the formation of the peripheral nervous system. Whereas other neural tube cells express N-cadherin, the dorsal neural tube containing neural crest precursors has little or no N-cadherin immunoreactivity. In contrast, N-CAM is expressed in the dorsal neural tube and on early migrating neural crest cells, from which it gradually disappears during migration. Both N-CAM and N-cadherin are absent from neural crest cells at advanced stages of migration. As neural crest cells cease migration and condense to form dorsal root and sympathetic ganglia, N-cadherin but not N-CAM is observed on the forming ganglia, identified by neurofilament expression and the aggregation of HNK-1 reactive cells. The results demonstrate that the absence of N-cadherin correlates with the onset of neural crest migration and its reappearance correlates with cessation of migration and precedes ganglio-genesis.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/aja.1001940103DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/aja.1001940103/abstractPublisherArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 1992 Wiley-Liss, Inc. Received April 27, 1992; accepted April 27, 1992. We thank Drs. Masatoshi Takeichi, Jack Lillien, David Gottlieb, and Virginia Lee for kindly providing the antibodies used in this study, Brad Martinsen for excellent technical assistance, and Drs. Thomas Lallier and Mark Selleck for helpful comments on the manuscript. This work was supported by USPHS DE10066 to M.B.F.
Funders:
Funding AgencyGrant Number
NIHDE10066
Subject Keywords:N-cadherin; N-CAM; Emigration; Gangliogenesis; Neural tube
Issue or Number:1
Record Number:CaltechAUTHORS:20160405-112342750
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160405-112342750
Official Citation:Akitaya, T. and Bronner-Fraser, M. (1992), Expression of cell adhesion molecules during initiation and cessation of neural crest cell migration. Dev. Dyn., 194: 12–20. doi: 10.1002/aja.1001940103
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65930
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:06 Apr 2016 18:47
Last Modified:03 Oct 2019 09:51

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