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Cardiotrophin-1 Induces the Same Neuropeptides in Sympathetic Neurons as Do Neuropoietic Cytokines

Cheng, Jr-Gang and Pennica, Diane and Patterson, Paul H. (1997) Cardiotrophin-1 Induces the Same Neuropeptides in Sympathetic Neurons as Do Neuropoietic Cytokines. Journal of Neurochemistry, 69 (6). pp. 2278-2284. ISSN 00223042. https://resolver.caltech.edu/CaltechAUTHORS:20160407-073653884

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Abstract

Cardiotrophin-1 (CT-1) was cloned from mouse embryoid body for its ability to induce growth of heart cells. Predictions of its secondary structure indicate that CT-1 belongs to a family of cytokines with a four-helical bundle structure, and sequence comparisons reveal a weak homology to leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF). Using a reverse transcriptase-polymerase chain reaction assay with rat sympathetic neuron cultures, we find that CT-1 induces and suppresses the expression of the same set of neuropeptide and neurotransmitter synthetic enzyme mRNAs as do LIF and CNTF. In addition, the effects of CT-1 and LIF are not additive, and CT-1 does not require a GPI-linked component to mediate its actions. Our functional data confirm that CT-1 is a member of the neuropoietic cytokine family and suggest that the CT-1 receptor complex contains the gp130 signal transducing component.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1046/j.1471-4159.1997.69062278.xDOIArticle
http://onlinelibrary.wiley.com/doi/10.1046/j.1471-4159.1997.69062278.x/abstractPublisherArticle
Additional Information:© 1997 International Society for Neurochemistry. Received May 9, 1997; revised manuscript received July 14, 1997; accepted July 14, 1997. Article first published online: 18 Nov 2002. We thank M. J. Fann for assistance with RT-PCR. This study was supported by a grant from NINDS to P.H.P. and a Gosney Fellowship to J.-G.C.
Funders:
Funding AgencyGrant Number
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
Caltech Gosney FellowshipUNSPECIFIED
Subject Keywords:gp130; Ciliary neurotrophic factor; Leukemia inhibitory factor; Cardiotrophin; Interleukin-6
Issue or Number:6
Record Number:CaltechAUTHORS:20160407-073653884
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160407-073653884
Official Citation:Cheng, J.-G., Pennica, D. and Patterson, P. H. (1997), Cardiotrophin-1 Induces the Same Neuropeptides in Sympathetic Neurons as Do Neuropoietic Cytokines. Journal of Neurochemistry, 69: 2278–2284. doi: 10.1046/j.1471-4159.1997.69062278.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65978
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:07 Apr 2016 17:40
Last Modified:03 Oct 2019 09:52

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