Cheng, Jr-Gang and Pennica, Diane and Patterson, Paul H. (1997) Cardiotrophin-1 Induces the Same Neuropeptides in Sympathetic Neurons as Do Neuropoietic Cytokines. Journal of Neurochemistry, 69 (6). pp. 2278-2284. ISSN 0022-3042. doi:10.1046/j.1471-4159.1997.69062278.x. https://resolver.caltech.edu/CaltechAUTHORS:20160407-073653884
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Abstract
Cardiotrophin-1 (CT-1) was cloned from mouse embryoid body for its ability to induce growth of heart cells. Predictions of its secondary structure indicate that CT-1 belongs to a family of cytokines with a four-helical bundle structure, and sequence comparisons reveal a weak homology to leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF). Using a reverse transcriptase-polymerase chain reaction assay with rat sympathetic neuron cultures, we find that CT-1 induces and suppresses the expression of the same set of neuropeptide and neurotransmitter synthetic enzyme mRNAs as do LIF and CNTF. In addition, the effects of CT-1 and LIF are not additive, and CT-1 does not require a GPI-linked component to mediate its actions. Our functional data confirm that CT-1 is a member of the neuropoietic cytokine family and suggest that the CT-1 receptor complex contains the gp130 signal transducing component.
| Item Type: | Article | |||||||||
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| Additional Information: | © 1997 International Society for Neurochemistry. Received May 9, 1997; revised manuscript received July 14, 1997; accepted July 14, 1997. Article first published online: 18 Nov 2002. We thank M. J. Fann for assistance with RT-PCR. This study was supported by a grant from NINDS to P.H.P. and a Gosney Fellowship to J.-G.C. | |||||||||
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| Subject Keywords: | gp130; Ciliary neurotrophic factor; Leukemia inhibitory factor; Cardiotrophin; Interleukin-6 | |||||||||
| Issue or Number: | 6 | |||||||||
| DOI: | 10.1046/j.1471-4159.1997.69062278.x | |||||||||
| Record Number: | CaltechAUTHORS:20160407-073653884 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160407-073653884 | |||||||||
| Official Citation: | Cheng, J.-G., Pennica, D. and Patterson, P. H. (1997), Cardiotrophin-1 Induces the Same Neuropeptides in Sympathetic Neurons as Do Neuropoietic Cytokines. Journal of Neurochemistry, 69: 2278–2284. doi: 10.1046/j.1471-4159.1997.69062278.x | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 65978 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Ruth Sustaita | |||||||||
| Deposited On: | 07 Apr 2016 17:40 | |||||||||
| Last Modified: | 04 Oct 2022 17:06 |
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