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SM37, a skeletogenic gene of the sea urchin embryo linked to the SM50 gene

Lee, Youn-Ho and Britten, Roy J. and Davidson, Eric H. (1999) SM37, a skeletogenic gene of the sea urchin embryo linked to the SM50 gene. Development, Growth & Differentiation, 41 (3). pp. 303-312. ISSN 0012-1592. doi:10.1046/j.1440-169X.1999.413429.x.

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The genomic DNA region that contains the SM50 gene also included a second gene that appeared to encode another skeletogenic matrix protein. The two genes were linked at a distance of about 12 kb. Based on the molecular weight of the implied protein the gene was termed SM37. The SM37 protein included a long tandem sequence of short glycine-rich repeats that was similar to the glycine-rich repeats included in the SM50 protein and several other skeletal matrix proteins, although the sequence of SM37 repeat was distinct. The overall structure of the SM37 protein was similar to SM50 as well. However, SM37 was only about 30% identical in amino acid sequence to SM50, and coding region probes behaved as a single copy sequence under standard conditions. The SM37 gene included the same cis-regulatory elements as the SM50 gene, although in a different order with respect to transcription. This gene was regulated coordinately with SM50 during development, and like SM50 was expressed exclusively in skeletogenic mesenchyme lineages.

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Additional Information:© 1999 Japanese Society of Developmental Biologists. Received 17 November 1998; revised 24 December 1998; accepted 6 January 1999. We are grateful to Dr Andrew Cameron for his careful review of this manuscript, and wish particularly to acknowledge the expert technical assistance of Miki Yun, who obtained and processed the sequence of l30. Dr Andrew Ransick was generous with his time and expertise in transferring to Y.H.L his in situ hybridization technology. Finally, we wish to thank Prof. Fred Wilt of UC Berkeley for his great collegiality and helpfulness in making available to us his unpublished protocols for isolation and culture of skeletogenic mesenchyme cells. This work was supported by the Office of Naval Research, California Sea Grant College Program, and by the Stowers Institute for Medical Research.
Funding AgencyGrant Number
Office of Naval Research (ONR)UNSPECIFIED
California Sea Grant College ProgramUNSPECIFIED
Stowers Institute for Medical ResearchUNSPECIFIED
Subject Keywords:embryogenesis; embryonic gene expression; gene linkage; skeletal matrix protein
Issue or Number:3
Record Number:CaltechAUTHORS:20160407-073654390
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Official Citation:Lee, Y.-H., Britten, R. J. and Davidson, E. H. (1999), SM37, a skeletogenic gene of the sea urchin embryo linked to the SM50 gene. Development, Growth & Differentiation, 41: 303–312. doi: 10.1046/j.1440-169X.1999.413429.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65980
Deposited By: Ruth Sustaita
Deposited On:07 Apr 2016 18:09
Last Modified:10 Nov 2021 23:51

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