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Generation of Neuronal Diversity: Analogies and Homologies with Hematopoiesis

Nawa, H. and Yamamori, T. and Le, T. and Patterson, P. H. (1990) Generation of Neuronal Diversity: Analogies and Homologies with Hematopoiesis. Cold Spring Harbor Symposia on Quantitative Biology, 55 . pp. 247-253. ISSN 0091-7451. https://resolver.caltech.edu/CaltechAUTHORS:20160407-073654687

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Abstract

The immense variety of neuronal phenotypes in the vertebrate nervous system is apparent in considering just the process of chemical transmission. There are approximately 12 known classical neurotransmitters and more than 30 neuropeptides thus far identified, and individual neurons simultaneously synthesize, store, and secrete one or more classical transmitters in addition to three or more neuropeptides. The transmitters and peptides are expressed in an exceedingly large number of different combinations in different parts of the nervous system. Although there are useful generalizations as to the frequency of certain transmitter-peptide combinations, there are innumerable exceptions to these rules. How the particular combinations produced in each neuron are specified during development is a challenging question. The magnitude of this problem becomes clear if one calculates the number of possible combinations if a neuron is to produce 2 transmitters out of a possible 12 and 3 peptides out of a possible 30. There are 267,960 different potential phenotypes in this example.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1101/SQB.1990.055.01.027DOIArticle
http://symposium.cshlp.org/content/55/247.extractPublisherArticle
Additional Information:© 1990 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, http://creativecommons.org/licenses/by-nc/4.0/). We are grateful to Dr. Donald Metcalf and colleagues of the Walter and Eliza Hall Institute for Medical Research in Melbourne for recombinant LIF. We thank D. McDowell for help with the preparation of tissue culture materials and J. Carnahan for preparation of NGF. This work was supported by the National Institute of Neurological Disorders and Stroke (Javits Neuroscience Investigator Award) and a McKnight Foundation Neuroscience Research Project Award (P.H.P.): by the Muscular Dystrophy Association, the Del Webb Foundation and the Japanese Ministry of Education, Science, and Culture (H.N.); by a Caltech Summer Undergraduate Research Fellowship (T.L.); and by the Alzheimer's Disease and Related Disorders Association (T.Y.).
Funders:
Funding AgencyGrant Number
National Institute of Neurological Disorders and Stroke (NINDS)UNSPECIFIED
McKnight FoundationUNSPECIFIED
Muscular Dystrophy AssociationUNSPECIFIED
Del Webb FoundationUNSPECIFIED
Ministry of Education, Science, and Culture (Japan)UNSPECIFIED
Caltech Summer Undergraduate Research Fellowship (SURF)UNSPECIFIED
Alzheimer's Disease and Related Disorders AssociationUNSPECIFIED
Record Number:CaltechAUTHORS:20160407-073654687
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160407-073654687
Official Citation:Generation of Neuronal Diversity: Analogies and Homologies with Hematopoiesis H. Nawa, T. Yamamori, T. Le, and P.H. Patterson Cold Spring Harb Symp Quant Biol 1990 55: 247-253; doi:10.1101/SQB.1990.055.01.027
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65981
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:07 Apr 2016 15:23
Last Modified:03 Oct 2019 09:52

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