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Recognition and Reaction of Metallointercalators with DNA

Erkkila, Kathryn E. and Odom, Duncan T. and Barton, Jacqueline K. (1999) Recognition and Reaction of Metallointercalators with DNA. Chemical Reviews, 99 (9). pp. 2777-2796. ISSN 0009-2665. doi:10.1021/cr9804341.

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The design of small complexes that bind and react at specific sequences of DNA becomes important as we begin to delineate, on a molecular level, how genetic information is expressed. A more complete understanding of how to target DNA sites with specificity will lead not only to novel chemotherapeutics but also to a greatly expanded ability for chemists to probe DNA and to develop highly sensitive diagnostic agents.

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Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 1999 American Chemical Society. Received May 17, 1999 Revised Manuscript Received July 5, 1999. Publication Date (Web): August 3, 1999. We are grateful to the NIH (GM33309) for their financial support. We also thank our many coworkers and collaborators, as cited, as well as the many researchers from other laboratories who helped elucidate the chemistry of metallointercalators.
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Issue or Number:9
Record Number:CaltechAUTHORS:20160407-115524676
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Official Citation:Recognition and Reaction of Metallointercalators with DNA Kathryn E. Erkkila, Duncan T. Odom, and Jacqueline K. Barton Chemical Reviews 1999 99 (9), 2777-2796 DOI: 10.1021/cr9804341
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:65993
Deposited By: Ruth Sustaita
Deposited On:11 Apr 2016 17:12
Last Modified:10 Nov 2021 23:52

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