Davidson, Eric H. (1999) A view from the genome: spatial control of transcription in sea urchin development. Current Opinion in Genetics and Development, 9 (5). pp. 530-541. ISSN 0959-437X. doi:10.1016/S0959-437X(99)00013-1. https://resolver.caltech.edu/CaltechAUTHORS:20160411-113222471
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Abstract
The process of embryogenesis depends on differential regulation of genes in the spatial components defined by the embryonic cells (blastomeres). Developmental regulation is mediated by complex, hardwired genomic control systems consisting of clusters of multiple target sites at which specific interactions with regionally presented transcription factors occur. In the age of genomics and gene-transfer technology, the sea urchin embryo provides unique opportunities for experimental analysis of these processes. Research on gene regulation in sea urchin embryos in the past year has seen remarkable progress in two large areas: in understanding functional cis-regulatory architecture; and in understanding the mechanism by which the axial coordinates of the egg are transduced into a molecular system for differential gene activation.
| Item Type: | Article | |||||||||
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| Additional Information: | © 1999 Elsevier Science Ltd. | |||||||||
| Issue or Number: | 5 | |||||||||
| DOI: | 10.1016/S0959-437X(99)00013-1 | |||||||||
| Record Number: | CaltechAUTHORS:20160411-113222471 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160411-113222471 | |||||||||
| Official Citation: | Eric H Davidson, A view from the genome: spatial control of transcription in sea urchin development, Current Opinion in Genetics & Development, Volume 9, Issue 5, 1 October 1999, Pages 530-541, ISSN 0959-437X, http://dx.doi.org/10.1016/S0959-437X(99)00013-1. (http://www.sciencedirect.com/science/article/pii/S0959437X99000131) | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 66050 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Ruth Sustaita | |||||||||
| Deposited On: | 11 Apr 2016 20:18 | |||||||||
| Last Modified: | 10 Nov 2021 23:52 |
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