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Molecular Characterization and Phylogenetic Analysis of SpBMP5–7, a New Member of the TGF-β Superfamily Expressed in Sea Urchin Embryos

Ponce, Maria R. and Micol, José L. and Peterson, Kevin J. and Davidson, Eric H. (1999) Molecular Characterization and Phylogenetic Analysis of SpBMP5–7, a New Member of the TGF-β Superfamily Expressed in Sea Urchin Embryos. Molecular Biology and Evolution, 16 (5). pp. 634-645. ISSN 0737-4038. https://resolver.caltech.edu/CaltechAUTHORS:20160411-144512549

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Abstract

TGF-β ligands are probably pan-bilaterian in phylogenetic distribution. The family appears to have diversified greatly with the evolution of the vertebrates, but only a few invertebrate deuterostome TGF-β molecules have so far been isolated. A search for members of this family expressed in sea urchin embryos, using canonical PCR primers, revealed a single-copy gene encoding a new TGF-β protein. The sequence which it encodes is closely related to those of vertebrate bone morphogenetic proteins (BMPs) 5-7. No additional TGF-β family members were uncovered other than univin, which had previously been reported.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://mbe.oxfordjournals.org/content/16/5/634.abstractPublisherArticle
Additional Information:© 1999 Society for Molecular Biology and Evolution. Accepted January 18, 1999. Stephen Palumbi, reviewing editor. This work was supported by NIH grant HD-05753 and NATO CRG 931023. M.R.P. was a fellow of Fundaciόn Rich. We are indebted to Markus Friedrich for assistance with the phylogenetic analyses and to R. Andrew Cameron for his careful review of a draft of this manuscript.
Funders:
Funding AgencyGrant Number
NIHHD-05753
North Atlantic Treaty Organization (NATO)CRG 931023
Subject Keywords:TGF-β superfamily, bone morphogenetic proteins, sea urchin embryogenesis
Issue or Number:5
Record Number:CaltechAUTHORS:20160411-144512549
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160411-144512549
Official Citation:M R Ponce, J L Micol, K J Peterson, and E H Davidson Molecular characterization and phylogenetic analysis of SpBMP5-7, a new member of the TGF-beta superfamily expressed in sea urchin embryos. Mol Biol Evol (1999) 16 (5): 634-645
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66056
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:12 Apr 2016 23:06
Last Modified:03 Oct 2019 09:53

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