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Leukemia Inhibitory Factor, Interleukin 6, and Other Cytokines Using the GP130 Transducing Receptor: Roles in Inflammation and Injury

Gadient, Reto A. and Patterson, Paul H. (1999) Leukemia Inhibitory Factor, Interleukin 6, and Other Cytokines Using the GP130 Transducing Receptor: Roles in Inflammation and Injury. Stem Cells, 17 (3). pp. 127-137. ISSN 1549-4918. https://resolver.caltech.edu/CaltechAUTHORS:20160412-091625896

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Abstract

Inflammation refers to a complex set of mechanisms by which tissues respond to injury and infection. Among the many soluble mediators associated with this process, cytokines are known to be crucial in regulating a variety of cellular and molecular events. Leukemia inhibitory factor (LIF), interleukin 6 (IL-6), IL-11, and possibly other members of this cytokine family are key mediators in various inflammatory processes such as the acute-phase reaction, tissue damage, and infection. These cytokines can act in both pro-inflammatory and anti-inflammatory ways, depending on a number of variables. We emphasize here recent work utilizing knockout mice, which has highlighted the roles of LIF and IL-6, particularly in interactions between the immune and nervous systems.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/stem.170127DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/stem.170127/fullPublisherArticle
Additional Information:© 1999 AlphaMed Press. Article first published online: 1 May 1999. The authors wish to thank the following for support of this research: National Institute for Neurological Disease and Stroke, McGrath Foundation, Spinal Cord Research Foundation, Della Martin Foundation, American Paralysis Association, Ralph L. Smith Foundation, Human Frontiers Science Program, and the Van Nuys Foundation (PHP); Novartis Pharma Research (RAG).
Funders:
Funding AgencyGrant Number
National Institute for Neurological Disease and Stroke UNSPECIFIED
McGrath FoundationUNSPECIFIED
Spinal Cord Research FoundationUNSPECIFIED
Della Martin FoundationUNSPECIFIED
American Paralysis AssociationUNSPECIFIED
Ralph L. Smith FoundationUNSPECIFIED
Human Frontiers Science ProgramUNSPECIFIED
Van Nuys FoundationUNSPECIFIED
Novartis Pharma ResearchUNSPECIFIED
Issue or Number:3
Record Number:CaltechAUTHORS:20160412-091625896
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160412-091625896
Official Citation:Gadient, R. A. and Patterson, P. H. (1999), Leukemia Inhibitory Factor, Interleukin 6, and Other Cytokines Using the GP130 Transducing Receptor: Roles in Inflammation and Injury. STEM CELLS, 17: 127–137. doi: 10.1002/stem.170127
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66075
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:12 Apr 2016 17:07
Last Modified:03 Oct 2019 09:53

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