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Cases of Ancient Mobile Element DNA Insertions That Now Affect Gene Regulation

Britten, Roy J. (1996) Cases of Ancient Mobile Element DNA Insertions That Now Affect Gene Regulation. Molecular Phylogenetics and Evolution , 5 (1). pp. 13-17. ISSN 1055-7903. https://resolver.caltech.edu/CaltechAUTHORS:20160412-104335578

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Abstract

There is no doubt that mobile elements are a major source of mutation and that in many cases insertions cause changes in the expression of genes, but a question remains open. What has the long-term effect of these processes been? The data collected here show that in many eukaryotes, segments of repetitive DNA (mobile elements) that have been inserted in the past in regions of many eukaryote genes have been preserved by selection and now affect the transcriptional control of these specific genes. At least five of the examples are considered to be solid cases demonstrating this history. There are a number of significant but less compelling sets of evidence that support the concept that the insertion of mobile elements in gene regions could be a major source of regulatory variation in evolution.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1006/mpev.1996.0003DOIArticle
http://www.sciencedirect.com/science/article/pii/S1055790396900032PublisherArticle
Additional Information:© 1996 by Academic Press, Inc. Received May 10, 1995; revised August 3, 1995.
Issue or Number:1
Record Number:CaltechAUTHORS:20160412-104335578
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160412-104335578
Official Citation:Roy J. Britten, Cases of Ancient Mobile Element DNA Insertions That Now Affect Gene Regulation, Molecular Phylogenetics and Evolution, Volume 5, Issue 1, February 1996, Pages 13-17, ISSN 1055-7903, http://dx.doi.org/10.1006/mpev.1996.0003. (http://www.sciencedirect.com/science/article/pii/S1055790396900032)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66084
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:12 Apr 2016 17:51
Last Modified:03 Oct 2019 09:53

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